Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, September 26, 2014

Living scaffolds for neuroregeneration

This sounds extremely important for our exercise generated neurogenesis to find their way to the correct locations. So ask your doctor what they are doing about contacting these researchers to make sure they are doing this correctly and creating good translational research that will directly help survivors.
http://www.sciencedirect.com/science/article/pii/S1359028614000540
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Highlights

Tissue engineered “living scaffolds” consist of cells in a defined 3D architecture.
Living scaffolds present cues to facilitate nervous system repair.
They mimic developmental mechanisms of axon growth and cell migration.
Living scaffolds modulate the regenerative environment based on local feedback.
They may elicit tissue reconstruction following neurodegenerative disease or trauma.

Abstract

Neural tissue engineers are exploiting key mechanisms responsible for neural cell migration and axonal pathfinding during embryonic development to create living scaffolds for neuroregeneration following injury and disease. These mechanisms involve the combined use of haptotactic, chemotactic, and mechanical cues to direct cell movement and re-growth. Living scaffolds provide these cues through the use of cells engineered in a predefined architecture, generally in combination with biomaterial strategies. Although several hurdles exist in the implementation of living regenerative scaffolds, there are considerable therapeutic advantages to using living cells in conjunction with biomaterials. The leading contemporary living scaffolds for neurorepair are utilizing aligned glial cells and neuronal/axonal tracts to direct regenerating axons across damaged tissue to appropriate targets, and in some cases to directly replace the function of lost cells. Future advances in technology, including the use of exogenous stimulation and genetically engineered stem cells, will further the potential of living scaffolds and drive a new era of personalized medicine for neuroregeneration.

Keywords

  • Tissue engineering;
  • Cell transplant;
  • Biomaterials;
  • Regeneration;
  • Neurotrauma;
  • Neurodegeneration;
  • Axon pathfinding;
  • Cell migration

Corresponding author at: 105E Hayden Hall/3320 Smith Walk, Philadelphia, PA 19104, United States. Tel.: +1 215 746 8176; fax: +1 215 573 3808.
1
The first two authors contributed equally to this manuscript.
2
Address: 373 Stemmler Hall/3450 Hamilton Walk, Philadelphia, PA 19104, United States. Tel.: +1 215 898 9218; fax: +1 215 573 3808.
3
Address: 502 Stemmler Hall/3450 Hamilton Walk, Philadelphia, PA 19104, United States. Tel.: +1 215 898 9218; fax: +1 215 573 3808.

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