http://www.mdlinx.com/internal-medicine/medical-news-article/2015/07/01/6216664/?
University of Michigan Health System, 07/01/2015
New
research suggests enzyme CD39 capable of clearing plaque that leads to
heart attacks, strokes. Staying active, never smoking and controlling
diabetes and cholesterol can prevent hardening of the arteries, but
effective treatment of atherosclerosis could come down to harnessing an
enzyme already built in to the blood vessels. In a new study published
online ahead of print in the August issue of The Journal of Clinical
Investigation, scientists at the University of Michigan Health System
used mice to show that a human membrane–bound enzyme called CD39, which
can clear the dangerous buildup of adenosine triphosphate (ATP) from the
bloodstream, significantly reduces atherosclerosis in mice. The enzyme
is known for its ability to control blood clots and reduce inflammation,
but the study led by Yogen Kanthi, M.D., and David Pinsky, M.D., is the
first to reveal a major role of CD39 in reducing atherosclerosis.
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