http://stroke.ahajournals.org/content/early/2015/07/02/STROKEAHA.115.010115.abstract?
Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study
- Renate M. Arntz, MD,
- Loes C.A. Rutten-Jacobs, PhD,
- Noortje A.M. Maaijwee, MD,
- Hennie C. Schoonderwaldt, MD, PhD,
- Lucille D.A. Dorresteijn, MD, PhD,
- Ewoud J. van Dijk, MD, PhD and
- Frank-Erik de Leeuw, MD, PhD
+ Author Affiliations
- Correspondence to Frank-Erik de Leeuw, MD, PhD, Department of Neurology, Radboudumc, PO Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail FrankErik.deLeeuw@radboudumc.nl
Abstract
Background and Purpose—Poststroke epilepsy is a common complication after a young stroke. We investigated the association between poststroke epilepsy
and mortality.
Methods—We
performed a prospective cohort study among 631 patients with a
first-ever transient ischemic attack or ischemic stroke,
aged 18 to 50 years. Survival analysis and
Cox proportional hazard analysis were used to estimate cumulative
mortality and
hazard ratios for patients with and without
epilepsy.
Results—After mean
follow-up of 12.5 years (SD 8.6), 76 (12.0%) developed poststroke
epilepsy. Case fatality was 27.4% for patients
with poststroke epilepsy and 2.1% for those
without. Poststroke epilepsy was associated with 30-day mortality
(hazard ratio,
4.8; 95% confidence interval, 1.7–14.0) and
long-term mortality (hazard ratio, 1.8; 95% confidence interval,
1.2–2.9).
Conclusions—Epilepsy is a common problem after a young stroke and is associated with an increased short-term and long-term mortality.
No comments:
Post a Comment