Deans' stroke musings: Effects of morning versus evening statin administration on lipid profile: A systematic review and meta-analysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, June 24, 2017

Effects of morning versus evening statin administration on lipid profile: A systematic review and meta-analysis

I have no clue whether my statins are short or long acting. So this is totally useless for laypersons and I bet your doctor will not be informing you of this.
https://www.mdlinx.com/internal-medicine/medical-news-article/2017/06/16/cholesterol-ldl-hydroxymethylglutaryl-coa-reductase-inhibitors/7213624/?news_id=387&newsdt=062417&subspec_id=4&utm_source=WeeklyNL&utm_medium=newsletter&utm_content=Weeks-Best-Article&utm_campaign=article-section&category=latest-weekly

Journal of Clinical Lipidology

Awad K, et al. – This study explored the impacts of morning versus evening statin administration on lipid profile. As per findings, evening–dose of short–acting statins markedly reduced low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels than morning–dose, whereas, long–acting statins exerted slight but significant impact on LDL-C and displayed equivalent efficacy for both regimens. Overall, it was recommended that long–acting statins should be given at a time that will best aid compliance, whereas, short–acting statins should be given in the evening.

Methods

Researchers searched PubMed, SCOPUS, Web of Science and Embase databases (from inception up to July 24th, 2016) to identify the relevant studies.
Using a fixed-effect model, they pooled mean differences (MDs) between the change scores in lipid parameters.

Results

For this analysis, eleven articles with 1034 participants were found to be eligible.
Researchers found that the pooled analysis comparing impacts of morning versus evening administration of statins on plasma total cholesterol (TC) (p=0.10), high density lipoprotein cholesterol (HDL-C) (p=0.90) and triglycerides (TG) (p=0.45) was not statistically significant.
They also noted that low density lipoprotein cholesterol (LDL-C) lowering was statistically greater in the evening-dose group (MD: 3.24 mg/dl, 95%CI: 1.23, 5.25, p=0.002).
It was demonstrated in subgroup analysis according to statin half-lives that evening-dose of statins was significantly superior to morning-dose for lowering LDL-C in case of both short and long half-life statins (MD: 9.68 mg/dl, 95%CI: 3.32, 16.03, p=0.003, and 2.53 mg/dl, 95%CI: 0.41, 4.64, p=0.02, respectively), and also for TC reduction in case of short half-life statins only (p=0.0005).