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MINNEAPOLIS,
Minn -- September 6, 2017 -- A simple scratch-and-sniff test may one
day be able to help identify some people at greater risk of developing
Parkinson’s disease up to 10 years before the disease could be
diagnosed, according to a study published in the September 6, 2017,
online issue of Neurology.
The study found that older adults with a poor sense of smell are more likely to develop Parkinson’s disease than people who perform better on the smell test. The researchers also found that the link was stronger in men than in women.
The test asks people to smell 12 common odours, such as cinnamon, lemon, gasoline, soap, and onion, and pick the correct answer from 4 choices.
The study was one of the first to look at the sense of smell and Parkinson’s disease in black people. Recent studies have shown the link in Asian and white people.
“Previous studies have shown that black people are more likely to have a poor sense of smell than whites and yet may be less likely to develop Parkinson’s disease,” said Honglei Chen, MD, Michigan State University College of Human Medicine, East Lansing, Michigan. “We found no statistical significance for a link between poor sense of smell and Parkinson’s disease in black people, but that may have been due to the small sample size. More research is needed to further investigate a possible link.”
The study involved 1,510 white people and 952 black people with an average age of 75 years who took the scratch-and-sniff test and were then followed for an average of 10 years. Then researchers looked to see who had developed Parkinson’s disease during that time. The participants were divided into 3 groups based on their scores on the smell test: poor sense of smell, medium, and good.
During the study, 42 people developed Parkinson’s disease: 30 white people and 12 black people. People in the poor sense of smell group were nearly 5 times more likely to develop the disease than people in the good sense of smell group. Of the 764 people with a poor sense of smell, 26 people developed Parkinson’s disease, compared with 7 of the 835 people with a good sense of smell and 9 of the 863 people with a medium sense of smell.
The results stayed the same after researchers adjusted for other factors that could affect risk of Parkinson’s disease, such as smoking, coffee drinking, and history of head injury.
The study showed a strong association between the smell test and development of Parkinson’s up to 6 years later. The association remained beyond 6 years, but was not as strong.
“Earlier studies had shown prediction of Parkinson’s disease about 4 to 5 years after the smell test was taken,” said Dr. Chen. “Our study shows that this test may be able to inform the risk much earlier than that.”
Dr. Chen noted that not everyone with low scores on the smell test will develop Parkinson’s disease. He said more research is needed before the smell test can be used to screen for Parkinson’s disease in the general population because the disease affects a low percentage of the population and because a low score on the test does not rule out other causes of problems with smelling.
He added that a limitation of the study was that while the study participants were followed over time, determining which participants developed Parkinson’s disease occurred at the end of the study, so it’s possible that some cases may have been missed or mistakes made, especially since the disease can take a long time to diagnose in some cases.
Reference: DOI: 10.1212/WNL.0000000000004382
SOURCE: American Academy of Neurology
The study found that older adults with a poor sense of smell are more likely to develop Parkinson’s disease than people who perform better on the smell test. The researchers also found that the link was stronger in men than in women.
The test asks people to smell 12 common odours, such as cinnamon, lemon, gasoline, soap, and onion, and pick the correct answer from 4 choices.
The study was one of the first to look at the sense of smell and Parkinson’s disease in black people. Recent studies have shown the link in Asian and white people.
“Previous studies have shown that black people are more likely to have a poor sense of smell than whites and yet may be less likely to develop Parkinson’s disease,” said Honglei Chen, MD, Michigan State University College of Human Medicine, East Lansing, Michigan. “We found no statistical significance for a link between poor sense of smell and Parkinson’s disease in black people, but that may have been due to the small sample size. More research is needed to further investigate a possible link.”
The study involved 1,510 white people and 952 black people with an average age of 75 years who took the scratch-and-sniff test and were then followed for an average of 10 years. Then researchers looked to see who had developed Parkinson’s disease during that time. The participants were divided into 3 groups based on their scores on the smell test: poor sense of smell, medium, and good.
During the study, 42 people developed Parkinson’s disease: 30 white people and 12 black people. People in the poor sense of smell group were nearly 5 times more likely to develop the disease than people in the good sense of smell group. Of the 764 people with a poor sense of smell, 26 people developed Parkinson’s disease, compared with 7 of the 835 people with a good sense of smell and 9 of the 863 people with a medium sense of smell.
The results stayed the same after researchers adjusted for other factors that could affect risk of Parkinson’s disease, such as smoking, coffee drinking, and history of head injury.
The study showed a strong association between the smell test and development of Parkinson’s up to 6 years later. The association remained beyond 6 years, but was not as strong.
“Earlier studies had shown prediction of Parkinson’s disease about 4 to 5 years after the smell test was taken,” said Dr. Chen. “Our study shows that this test may be able to inform the risk much earlier than that.”
Dr. Chen noted that not everyone with low scores on the smell test will develop Parkinson’s disease. He said more research is needed before the smell test can be used to screen for Parkinson’s disease in the general population because the disease affects a low percentage of the population and because a low score on the test does not rule out other causes of problems with smelling.
He added that a limitation of the study was that while the study participants were followed over time, determining which participants developed Parkinson’s disease occurred at the end of the study, so it’s possible that some cases may have been missed or mistakes made, especially since the disease can take a long time to diagnose in some cases.
Reference: DOI: 10.1212/WNL.0000000000004382
SOURCE: American Academy of Neurology
These statistics are not very impressive. I think I will stop trying to smell gas when I light a burner on my stove.
ReplyDeleteThese statistics are not very impressive. I think I will stop trying to smell gas when I light a burner on my stove.
ReplyDelete