Deans' stroke musings: Melatonin May Improve Your Memory, New Study Suggests

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, August 23, 2023

Melatonin May Improve Your Memory, New Study Suggests

What about this? Your doctor is incompetent if s/he doesn't know about that research. I take no prisoners is trying have stroke solved, a lot of dead wood needs to be removed; probably including your doctor.

Does Melatonin Cause Dementia? March 2023

Melatonin May Improve Your Memory, New Study Suggests

People having trouble falling asleep frequently turn to melatonin to help prepare themselves for bed. Some users may wake up feeling groggy, leading one to wonder if it could do more harm than good for our brains while we sleep. On the contrary, studies have shown the memory-enhancing effects of melatonin on animals, and new research out of Japan demonstrates that the benefits happen on a molecular level.

Scientists at Sophia University in Tokyo were able to pinpoint the microscopic changes that happen in mouse brains when given melatonin or any of its derivatives. They examined the effects of three compounds on memory formation: melatonin; N1-acetyl-5-methoxyquinuramine (AMK), melatonin’s biological metabolite; and ramelteon, a drug that binds and activates the melatonin receptor.

The formation of both short- and long-term memories requires the phosphorylation, or biochemical addition of phosphate groups to protein structures, of certain memory-related proteins. As such, the researchers explored the effects of protein extracellular signal-regulated kinase (ERK), calcium/calmodulin-dependent kinase IIα (CaMKIIα), CaMKIIβ, CaMKIV, and the cAMP-response element binding protein (CREB).

View on Watch “Our study aimed to investigate the effects of melatonin, ramelteon, and N1-acetyl-5-methoxyquinuramine (AMK) on the relative phosphorylation levels of memory-related proteins in order to explore candidate signaling pathways associated with the receptor- and nonreceptor-mediated memory-enhancing effects of melatonin," lead author Atsuhiko Chiba said of the study. Related: How Running Can Help Jog Your MemoryIn the end, they found that melatonin is apparently part of the process of creating long-term memories."Our findings suggest that melatonin is involved in promoting the formation of long-term object recognition memory by modulating the phosphorylation levels of memory-related proteins such as ERK, CaMKIIs, and CREB in both receptor-mediated and nonreceptor-mediated signaling pathways," Chiba concluded. People having trouble falling asleep frequently turn to melatonin to help prepare themselves for bed. Some users may wake up feeling groggy, leading one to wonder if it could do more harm than good for our brains while we sleep. On the contrary, studies have shown the memory-enhancing effects of melatonin on animals, and new research out of Japan demonstrates that the benefits happen on a molecular level. Scientists at Sophia University in Tokyo were able to pinpoint the microscopic changes that happen in mouse brains when given melatonin or any of its derivatives. They examined the effects of three compounds on memory formation: melatonin; N1-acetyl-5-methoxyquinuramine (AMK), melatonin’s biological metabolite; and ramelteon, a drug that binds and activates the melatonin receptor. The formation of both short- and long-term memories requires the phosphorylation, or biochemical addition of phosphate groups to protein structures, of certain memory-related proteins. As such, the researchers explored the effects of protein extracellular signal-regulated kinase (ERK), calcium/calmodulin-dependent kinase IIα (CaMKIIα), CaMKIIβ, CaMKIV, and the cAMP-response element binding protein (CREB). View on Watch“Our study aimed to investigate the effects of melatonin, ramelteon, and N1-acetyl-5-methoxyquinuramine (AMK) on the relative phosphorylation levels of memory-related proteins in order to explore candidate signaling pathways associated with the receptor- and nonreceptor-mediated memory-enhancing effects of melatonin," lead author Atsuhiko Chiba said of the study. The team is hopeful that the results of the study will contribute to the development of new drugs that can improve memory function in people suffering from age-related memory impairment. As the global population grows older, it would certainly be a welcome advancement. For now, it may be time to stock up on melatonin gummies.