Deans' stroke musings: Biomarkers associated with functional improvement after stroke rehabilitation: A systematic review and meta-analysis of randomized controlled trials

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, August 30, 2023

Biomarkers associated with functional improvement after stroke rehabilitation: A systematic review and meta-analysis of randomized controlled trials

Anyone researching biomarkers is not solving stroke and I would fire them all immediately with cause.

Biomarkers associated with functional improvement after stroke rehabilitation: A systematic review and meta-analysis of randomized controlled trials

Gengbin Chen^{1, 2}

Manfeng Wu² Jialin Chen¹ Cailing Zhang³ Quan Liu¹ Yinchun Zhao¹

Guang-qing Xu⁴

Yue Lan^5*

¹Guangzhou Sport University, China
²Guangzhou First People's Hospital, China
³South China University of Technology, China
⁴Guangdong Provincial People's Hospital, China
⁵Department of Rehabilitation Medicine, Guangzhou First People's Hospital, China

The final, formatted version of the article will be published soon.

Objective:

This study aims to identify blood and cerebrospinal fluid biomarkers that are correlated to the functional improvement of stroke patients after rehabilitation therapy, and provide ideas for the treatment and evaluation of stroke patients.The PubMed, Web of Science, and Embase databases were searched for articles published in the English language, from inception to December 8, 2022.

Results:

A total of 9,810 independent records generated 50 high-quality randomized controlled trials on 119 biomarkers. Among these records, 37 articles were included for the meta-analysis (with a total of 2,567 stroke patients), and 101 peripheral blood and cerebrospinal fluid biomarkers were included for the qualitative analysis. The quantitative analysis results revealed a moderate quality evidence that stroke rehabilitation significantly increased the level of brain-derived neurotrophic factor (BDNF) in serum. Furthermore, the low-quality evidence revealed that stroke rehabilitation significantly increased the concentration of serum noradrenaline (NE), peripheral blood superoxide dismutase (SOD), peripheral blood albumin (ALB), peripheral blood hemoglobin (HB), and peripheral blood catalase (CAT), but significantly decreased the concentration of serum endothelin (ET) and glutamate. In addition, the changes in concentration of these biomarkers were associated with significant improvements in post-stroke function. The serum BNDF suggests that this can be used as a biomarker for non-invasive brain stimulation (NIBS) therapy, and to predict the improvement of stroke patients.The concentration of serum BNDF, NE, ET and glutamate, and peripheral blood SOD, ALB, HB and CAT may suggest the function improvement of stroke patients.

Keywords: Meta-analysis, Rehabilitation, biomarker, Blood, function, Stroke

Received: 20 Jun 2023; Accepted: 25 Aug 2023.

Copyright: © 2023 Chen, Wu, Chen, Zhang, Liu, Zhao, Xu and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.