Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, January 10, 2024

Adiposity and Functional Outcome After Ischemic Stroke

 This means that your doctor has more work to do to get you 100% recovered if you have this issue. Don't let your doctor off the hook of 100% recovery by quoting the craptastic saying: 'All strokes are different, all stroke recoveries are different'. If you hear that fire them and find a better doctor

Adiposity and Functional Outcome After Ischemic Stroke


A Mendelian Randomization Study

Mengmeng Wang, MD https://orcid.org/0000-0002-9890-8900, Zhizhong Zhang, PhD, Iyas Daghlas, MD https://orcid.org/0000-0001-6924-0641, Dipender Gill, MD, PhD https://orcid.org/0000-0001-7312-7078, Dandan Liu, MD, and Xuegan Lian, PhDAuthors Info & Affiliations
February 13, 2024 issue
102 (3)
https://doi.org/10.1212/WNL.0000000000208080

    • Abstract

    Background and Objectives

    To investigate the causal relationships of abdominal adiposity (waist-to-hip ratio [WHR]) and overall adiposity (body mass index [BMI]) with functional outcome after ischemic stroke using Mendelian randomization.

    Methods

    Genetic instruments for WHR and BMI were obtained from the largest available genome-wide association studies meta-analysis of the Genetic Investigation of ANthropometric Traits consortium and the UK Biobank (N max = 806,834). Functional outcome after ischemic stroke was assessed using the modified Rankin Scale (mRS) score at 3-month after stroke onset, with mRS >2 (mRS 3–6) defined as an unfavorable functional outcome. Corresponding genetic estimates for an unfavorable functional outcome were extracted from the Genetics of Ischemic Stroke Functional Outcome network (N = 6,021). We applied a random-effects inverse variance weighted method as our main analysis.

    Results

    Genetically predicted higher WHR (per 0.09 ratio units) was associated with unfavorable functional outcome after ischemic stroke (mRS 3–6, OR = 1.48; 95% CI = 1.03–2.13; p = 0.033). The results remained directionally consistent in sensitivity analyses. Conversely, genetically predicted BMI (per 4.8 kg/m2) was not associated with unfavorable functional outcome after ischemic stroke (OR = 1.01; 95% CI = 0.75–1.36; p = 0.937).

    Discussion

    This study provides genetic evidence supporting the hypothesis that abdominal adiposity has a detrimental effect on functional recovery after ischemic stroke.
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