Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, July 18, 2013

Statin Study: No Impact on Cognition

Sorry but I don't think this study proved anything, they were looking for signs of dementia whereas the original problem reported was reduced cognition which I'm sure wasn't tested for as part of the studies looked at.
Do Statins Make You Stupid?
But let your doctor have their explanation of this.
http://www.medpagetoday.com/MeetingCoverage/AAIC/40514
A meta-analysis that included more than 40,000 patients found no indication that treatment with statins negatively impacted cognition, researchers reported here.
In responding to FDA concerns about possible adverse cognitive events, Brian Ott, MD, professor of medicine at Alpert Medical School of Brown University, Providence, RI, said his review of the medical literature found no statistically significant differences in cognition between those patients on statins and patients not taking the cholesterol-lowering drugs.
"These results raise questions regarding the continued merit of the FDA warning about potential effects of statins on cognition," Ott told MedPage Today at his poster presentation at the Alzheimer's Association International Conference. "The issue has major public health implications due to decisions by patients and physicians to discontinue statin therapy in the primary and secondary prevention of cardiovascular and cerebrovascular death and morbidity."
He said that when the FDA issued its report, "unfortunately, a lot of people took that to heart and stopped the statins on their own. That concerned me, so I wanted to look at the accumulated data. This is just our first look at the data and we don't really see anything."
Ott also said the early review did not show there were differences when it came to the type of statin, whether lipophilic or hydrophilic.
In commenting on the study, Gus Alva, MD, medical director of the ATP Clinical Research, Inc., told MedPage Today, "If I had a patient with high cholesterol I would always put them on statins. However, with older patients you have to be aware of muscle cramping that can be associated with statin use."
Ott and colleagues reviewed medical literature on the topic of reports of dementia or nervous system side effects in multiple clinical trials. For example, he cited the 17,802-person Jupiter study, in which dementia was observed in 12 (0.1%) of patients on rosuvastatin compared with 9 (0.1%) of patients on placebo. In the same study, adverse nervous system events were reported by 69 (0.8%) patients on rosuvastatin and by 76 (0.9%) of patients on placebo.
"Among over 468 other phase 2 or phase 3 randomized clinical trials that we reviewed, none reported adverse cognitive events,"(but were they even checking for cognitive problems? no checking leads to no reported problems) Ott said. "Overall, our preliminary meta-analyses of cognitive test data showed no significant effects on global cognition or on specific cognitive domains for subjects with normal cognition as well as those with Alzheimer's disease."
"Adverse cognitive outcomes attributable to statins were rarely if ever reported in randomized clinical trials," he said. "The systemic review was consistent with prior reviews finding no significant relationship between cognitive decline or adverse cognitive evens and the use of any statin drug in cognitively healthy people as well as those with dementia."
"Furthermore, the meta-analysis failed to show significant adverse effects of statins on cognition from the combined data in either patient group," he said. "The medical benefits of being on a statin far outweigh the possible [advent] of cognition problems."

Primary source: Alzheimer's Association International Conference
Source reference:
Ott B, et al "Do statin drugs impair cognition? A systematic review and meta-analysis" AAIC 2013; DOI: Abstract P3-298. 

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