This sounds great, it can join the other 177 hyperacute possibilities.
http://www.redorbit.com/news/health/1112904627/a-new-player-in-brain-disease-and-stroke/
In degenerative brain diseases and after stroke, nerve cells die
while their support cells activate the brain’s immune system to cause
further damage. Called the neuronal cascade of death. Now Jonathan Gilthorpe, Adrian Pini and Andrew Lumsden
at the MRC Centre for Developmental Neurobiology at King’s College
London, have found that a single protein, histone H1, causes these
distinct outcomes.
The research passed peer review within a week of being published in
F1000Research, where Jan-Marino Ramirez, of the University of
Washington, called the work “a very important contribution to our
understanding of neurodegenerative disease and the response of the brain
to injury” in his public referee report. He also noted that he is
“confident that this study will be a much cited contribution to the
field of traumatic brain injury”.
The most unexpected finding in this study is that a histone protein
is responsible for neuronal damage. “Histone H1 partners with DNA in the
cell nucleus and has been thought of as harmless,” explain the authors,
“The surprise came when we discovered that it can be released from
brain cells upon injury, killing healthy nerve cells and activating the
damaging immune response”.
The research team is now working on ways to suppress these harmful
actions, which may lead to the development of new treatments for
neurodegenerative disease and stroke.
No comments:
Post a Comment