http://www.thealmagest.com/2013/07/triglycerides-are-stroke-risk/
After some more tries, this research is from 2001.
Abstract
Background—
Despite unclear associations between blood lipids, including
fractionated cholesterol and triglycerides, and stroke, recent
evidence demonstrates that lipid-modifying
agents decrease the risk of stroke in patients with coronary heart
disease (CHD).
Methods and Results—
Patients with documented CHD who were screened for but not included in
the Bezafibrate Infarction Prevention study and had
no history of stroke or transient ischemic
attack (TIA) (n=11 177) were followed up. At baseline, medical histories
were obtained
and blood lipids assessed at a central study
laboratory. During a 6- to 8-year follow-up period, 941 patients were
identified
as having nonhemorrhagic cerebrovascular
disease, of whom 487 had verified ischemic stroke (per clinical findings
and brain
CT) or TIA. Patients experiencing an ischemic
stroke/TIA had higher mean levels of triglycerides, lower levels of HDL
cholesterol,
and lower percentages of cholesterol contained
in the HDL cholesterol moiety (%HDL; P<0.01 for all). In a
logistic regression model, the adjusted ORs for developing an ischemic
stroke/TIA were 1.27 (95% CI 1.01
to 1.60) associated with triglycerides >200
mg/dL and 0.87 (95% CI 0.78 to 0.97) associated with a 5% decrease in
%HDL. The
increased risk associated with high
triglycerides was found across subgroups of age, sex, patient
characteristics, and cholesterol
fractions.
Conclusions—
High triglycerides constitute an independent risk factor for ischemic
stroke/TIA across subgroups of age, sex, patient characteristics,
and cholesterol fractions, whereas high %HDL was
an independent protective factor among patients with CHD. These
findings
support the role of blood lipids, including
triglycerides, as important modifiable stroke risk factors.
No comments:
Post a Comment