http://nnr.sagepub.com/content/early/2015/05/06/1545968315586464.abstract?
- Raffaella Chieffo, MD, PhD1
- Giancarlo Comi, MD1
- Letizia Leocani, MD, PhD1
- Raffaella Chieffo, MD, PhD, Neurological Department and Institute of Experimental Neurology—INSPE, Scientific Institute Hospital San Raffaele, Via Olgettina 48, 20133 Milan, Italy. Email: raffaella.chieffo@hsr.it
Abstract
Walking rehabilitation is one of the
primary goals in stroke survivors because of its great potential for
recovery and its
functional relevance in daily living activities.
Although 70% to 80% of people in the chronic poststroke phases are able
to
walk, impairment of gait often persists, involving
speed, endurance, and stability. Walking involves several brain regions,
such as the sensorimotor cortex, supplementary
motor area, cerebellum, and brainstem, which are approachable by the
application
of noninvasive brain stimulation (NIBS). NIBS
techniques, such as repetitive transcranial magnetic stimulation and
transcranial
direct current stimulation, have been reported to
modulate neural activity beyond the period of stimulation, facilitating
neuroplasticity. NIBS methods have been largely
applied for improving paretic hand motor function and stroke-associated
cognitive
deficits. Recent studies suggest a possible
effectiveness of these techniques also in the recovery of poststroke
gait disturbance.
This article is a selective review about functional
investigations addressing the mechanisms of lower-limb motor system
reorganization
after stroke and the application of NIBS for
neurorehabilitation.
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