Deans' stroke musings: Coordinating neurons with blood vessels

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 30, 2015

Coordinating neurons with blood vessels

We need this for both neurogenesis and stem cells. What is your doctor doing to follow up on this line of therapy? It may not help us in time but future survivors will need this.
http://www.sciencemag.org/content/348/6238/986.1.full?
Science 29 May 2015:
Vol. 348 no. 6238 p. 986
DOI: 10.1126/science.348.6238.986-a

Pamela J. Hines

Neurons and blood vessels in the retina

PHOTO: THOMAS DEERINCK/NCMIR/SCIENCE SOURCE

The retina develops as interleaved layers of neurons and blood vessels. Usui et al. show that in mice, the development of blood vessel layers depends on signals from amacrine cells, a type of interneuron in the retina. Too much or too little signal resulted in too many or too few blood vessels, particularly affecting the intermediate vascular plexus (a network of blood vessels) embedded within the retina. This cellular crosstalk coordinates neuronal demand for oxygen with the blood's ability to supply it. With the intermediate vascular plexus poorly formed, photoreceptors (a type of neuron) degenerate, leading to deficits in vision.

J. Clin. Invest. 10.1172/JCI80297 (2015).