http://www.ncbi.nlm.nih.gov/pubmed/27063107
Abstract
Stroke survivors are often affected by psychological distress and neuropsychiatric disturbances. About one-third of stroke survivors experience depression, anxiety or apathy, which are the most common neuropsychiatric sequelae of stroke.
Neuropsychiatric sequelae are disabling, and can have a negative
influence on recovery, reduce quality of life and lead to exhaustion of
the caregiver. Despite the availability of screening instruments and
effective treatments, neuropsychiatric disturbances attributed to stroke are currently underdiagnosed and undertreated. Stroke severity, stroke-related
disabilities, cerebral small vessel disease, previous psychiatric
disease, poor coping strategies and unfavourable psychosocial
environment influence the presence and severity of the psychiatric
sequelae of stroke. Although consistent associations between psychiatric disturbances and specific stroke
locations have yet to be confirmed, functional MRI studies are
beginning to unveil the anatomical networks that are disrupted in stroke-associated psychiatric disorders. Evidence regarding biochemical and genetic biomarkers for stroke-associated
psychiatric disorders is still limited, and better understanding of the
biological determinants and pathophysiology of these disorders is
needed. Investigation into the management of these conditions must be
continued, and should include pilot studies to assess the benefits of
innovative behavioural interventions and large-scale cooperative
randomized controlled pharmacological trials of drugs that are safe to
use in patients with stroke.
- PMID:
- 27063107
- [PubMed - in process]
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