Would this help in post-stroke inflammation? We'll never know.
http://www.ncbi.nlm.nih.gov/pubmed/19670961
Abstract
BACKGROUND:
The
non-receptor spleen tyrosine kinase (Syk; EC 2.7.10.2) is involved in
signal transduction in a variety of cell types. In particular, it is a
key mediator of immune receptors signaling in host inflammatory cells (B
cells, mast cells, macrophages and neutrophils), important for both
allergic and antibody-mediated autoimmune diseases. Deregulated Syk
kinase activity also allows growth factor-independent proliferation and
transforms bone marrow-derived pre-B cells that are able to induce
leukemia. Consequently, the development of Syk kinase inhibitors could
conceivably treat these disorders and so they have became a major focus
in the pharmaceutical and biotech industry.
OBJECTIVE:
In
this review, we analyze the structure and role of Syk kinase, the use
of small molecules, interacting with ATP-binding site, as inhibitors of
kinase activity and finally the potential of using inhibitors of Syk
kinase expression to attenuate pathological conditions.
CONCLUSION:
Syk kinase inhibition is suggested as a powerful tool for the therapy of different pathologies.
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