Now all we have to do if find an intervention that promotes brain recovery that needs to get thru the blood brain barrier. That a job for 'super stroke leader'.
Adult human dental pulp stem cells promote blood–brain barrier permeability through vascular endothelial growth factor-a expression
- 1Stroke Research Programme, School of Medicine, University of Adelaide, Adelaide, Australia
- 2Centre for Stem Cell Research, Robinson Institute, Adelaide, Australia
- 3Department of Neurology, Queen Elizabeth Hospital, Woodville, Australia
- Simon A Koblar, School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia. Email: simon.koblar@adelaide.edu.au
Abstract
Stem cell therapy is a promising new
treatment option for stroke. Intravascular administration of stem cells
is a valid approach
as stem cells have been shown to transmigrate the
blood–brain barrier. The mechanism that causes this effect has not yet
been
elucidated. We hypothesized that stem cells would
mediate localized discontinuities in the blood–brain barrier, which
would
allow passage into the brain parenchyma. Here, we
demonstrate that adult human dental pulp stem cells express a soluble
factor
that increases permeability across an in vitro
model of the blood–brain barrier. This effect was shown to be the result
of
vascular endothelial growth factor-a. The effect
could be amplified by exposing dental pulp stem cell to stromal-derived
factor
1, which stimulates vascular endothelial growth
factor-a expression. These findings support the use of dental pulp stem
cell
in therapy for stroke.(No, it doesn't, getting thru the barrier is not a therapy in itself)
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