Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, November 24, 2017

Coffee: No Harm, No Foul If Only 4 Cups Daily

I bet your incompetent stroke hospital will not create a 24 hour a day coffee station. And if you are not catheterized this is great therapy for walking to the bathroom in time. There are NO excuses for such incompetence.
https://www.medpagetoday.com/primarycare/dietnutrition/69484?
However, link seen between coffee drinking and fracture risk in women
by Alexandria Bachert MPH, Staff Writer, MedPage Today
November 22, 2017
Daily consumption of coffee is safe within usual patterns of intake and more likely to benefit health than to harm it, British researchers concluded.
Analysis of more than 200 studies found that drinking three to four cups of coffee a day (400 mg/day) was associated with a reduced risk of all cause mortality (relative risk 0.83, 95% CI 0.83-0.88), cardiovascular mortality (0.81, 95% CI 0.72-0.90), and cardiovascular disease (0.85, 95% CI 0.80-0.90), reported Robin Poole, MD, of the University of Southampton in England, and colleagues.
Increasing consumption to more than three cups a day was not linked to harmful effects, but the benefit was less pronounced, they wrote online in BMJ.
Poole's group searched PubMed, Embase, CINAHL, and the Cochrane Database of Systematic Reviews for meta-analyses of observational or interventional studies that investigated the link between coffee consumption and any health outcome. Searching for "coffee OR caffeine" and "systematic review OR meta-analysis," they found 201 meta-analyses of observational research with 67 unique outcomes and 17 meta-analyses of randomized controlled trials with nine unique outcomes.
A meta-analysis of 40 cohort studies showed a lower incidence of cancer for high versus low coffee consumption (relative risk 0.82, 95% CI 0.74 to 0.89), any versus no consumption (RR 0.87, 95% CI 0.82-0.92), and one additional cup per day (RR 0.97, 95% CI 0.96-0.98), they reported.
Any versus no coffee consumption was associated with a 29% lower risk of non-alcoholic fatty liver disease (relative risk 0.71, 95% CI 0.60-0.85), a 27% lower risk for liver fibrosis (odds ratio 0.73, 95% CI 0.56-0.94), and a 39% lower risk for liver cirrhosis (OR 0.61, 95% CI 0.45-0.84), as well as a lower risk of cirrhosis with high versus low consumption (OR 0.69, 95% CI 0.44-1.07).
Additionally, coffee consumption was consistently associated with a lower risk of type 2 diabetes for high versus low consumption (RR 0.70, 95% CI 0.65-0.75) and Alzheimer's disease (RR 0.73, 95% CI 0.55-0.97).
Poole's group didn't find any consistent evidence of harmful associations between coffee consumption and health outcomes except for those related to pregnancy and risk of fracture in women. After adjustment for smoking, consumption in pregnancy was associated with harmful outcomes related to low birth weight (OR 1.31, 95% CI 1.03-1.67), preterm birth in the first trimester (OR 1.22, 95% CI 1.00-1.49), and second trimester (OR 1.12, 95% CI 1.02-1.22), and pregnancy loss (OR 1.46, 95% CI 1.06-1.99).
A research limitation was that much of the evidence was low quality and came from observational studies which may include residual confounding. However, the researchers noted that "the analysis indicates that future randomised controlled trials in which the intervention is increasing coffee consumption, within usual levels of intake, possibly optimised at three to four cups a day, would be unlikely to result in significant harm to participants."
In an accompanying editorial, Eliseo Guallar, MD, of Johns Hopkins Bloomberg School of Public Health in Baltimore, agreed but cited several suggestions regarding future research. "Poole and colleagues argue that randomised clinical trials are needed, although the complexity of long term trials of behavioural interventions, the large sample size required, and the high cost complicate the feasibility of trials prospectively testing the effect of coffee on clinical endpoints."
"Mendelian randomisation analyses may also help, but their power is limited if genetic traits explain only a small fraction of coffee intake patterns, and their interpretation is complicated by the pleiotropic effects of the genes involved in metabolising caffeine," Guallar noted.
Poole and co-authors disclosed no relevant relationships with industry.
Primary Source
BMJ
Source Reference: Guallar E "Coffee gets a clean bill of health" BMJ 2017; DOI: 10.1136/bmj.j5356.
Secondary Source
BMJ
Source Reference: Poole R, et al "Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes" BMJ 2017; DOI: 10.1136/bmj.j5024.

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