Deans' stroke musings: The aversive effects of cough suppressants on neurogenesis and emotional behaviour : chronic exposure to a common active ingredient in cough suppressants causes emotional disturbances through the suppression of adult neurogenesis, and their prevention by wolfberry polysaccharide in rats

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 21, 2017

The aversive effects of cough suppressants on neurogenesis and emotional behaviour : chronic exposure to a common active ingredient in cough suppressants causes emotional disturbances through the suppression of adult neurogenesis, and their prevention by wolfberry polysaccharide in rats

Your doctor should be warning you about abusing cough syrup leading to less neurogenesis.
http://ira.lib.polyu.edu.hk/handle/10397/70294
Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70294
Authors:

	Po, Kai Ting
Advisors:	Lau, Benson (RS)
Keywords:	Medication abuse Drug addiction Drug addiction -- Treatment Lycium chinense -- Therapeutic use
Issue Date:	2017
Publisher:	The Hong Kong Polytechnic University
Abstract:	Cough syrup abuse is a worldwide problem with increasing prevalence, causing chronic disability to abusers. Clinical studies have revealed that abusive consumption of the cough medicine can lead to various psychiatric signs and symptoms including delusion, hallucination, anxiety and depression. These persistent psychiatric symptoms not only disturb the abusers, but are also heavy burdens to the healthcare system. However, the underlying mechanisms of these adverse effects remain elusive. In order to investigate the mechanisms as well as the possible adjunctive treatments, the objectives of the present study are: 1. To explore the effect of repeated, high-dose dextromethorphan (DXM, a common antitussive component in cough syrup) treatment on adult hippocampal neurogenesis; 2. to study the dose-response effect of DXM on neurogenesis, and 3. to investigate the potential effect of wolfberry (a traditional Chinese herb) polysaccharide on reducing emotional distress caused by repeated treatment of DXM. The results revealed that high-dose DXM treatment induced mood disturbances and suppressed neurogenesis, while wolfberry polysaccharide could reverse the undesirable effects. These findings suggest that neurogenesis may be an underlying mechanisms of emotional symptoms induced by DXM, and the result also provided insights for using wolfberry polysaccharide, an herbal component, as a possible adjunctive treatment for the rehabilitation of cough syrup abusers suffering from emotional signs and symptoms.
Description:	126 pages : color illustrations PolyU Library Call No.: [THS] LG51 .H577M RS 2017 Po
URI:	http://hdl.handle.net/10397/70294
Rights:	All rights reserved.
Appears in Collections:	Thesis