http://stroke.ahajournals.org/content/48/12/3203?etoc=
Results From 2 Prospective Cohort Studies
Abstract
Background and Purpose—Higher
intake of whole grains may exert cardiometabolic benefits, although
findings on stroke risk are inconclusive. The potentially differential
effects of individual whole grain foods on ischemic stroke have not been
examined.
Methods—We
analyzed whole grain consumption in relation to ischemic stroke among
71 750 women from the Nurses’ Health Study and 42 823 men from the
Health Professionals Follow-up Study who were free of cardiovascular
disease, diabetes mellitus, and cancer at baseline (1984 and 1986,
respectively) through 2010 using a Cox proportional hazards model.
Validated semiquantitative food frequency questionnaires were used to
assess consumption of whole grain intake, including whole grain cold
breakfast cereal, dark bread, oatmeal, brown rice, popcorn, bran, and
germ. Self-reported incident cases of ischemic stroke were confirmed
through medical record review.
Results—During
2 820 128 person-years of follow-up in the 2 cohorts, 2458 cases of
ischemic stroke were identified and confirmed. Intake of total whole
grains was not associated with risk of ischemic stroke after adjustment
for covariates: the pooled hazard ratio (95% confidence interval)
comparing extreme intake levels was 1.04 (0.91–1.19). However, intake of
whole grain cold breakfast cereal and total bran was inversely
associated with ischemic stroke after multivariate adjustment: the
pooled hazard ratios (95% confidence intervals) were 0.88 (0.80–0.96; Ptrend=0.008) and 0.89 (0.79–1.00; Ptrend=0.004), respectively. Other whole grain foods were not associated with a lower risk of ischemic stroke.
Conclusions—Although
overall consumption of whole grains was not associated with lower risk
of ischemic stroke, greater consumption of whole grain cold breakfast
cereal and bran was significantly associated with a lower risk of
ischemic stroke. More studies are needed to replicate these associations
between individual whole grain foods and risk of ischemic stroke among
other populations.
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