My reading of this is that stress negatively affects blood flow, obviously with no medical knowledge on my own. So with the massive amount of stress your doctor is causing you by not giving you any clear way to get 100% recovered you are in more danger because lower blood flow negatively impacts your recovery. Your doctor is worsening your recovery.
The brain’s hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers
- Edited by Bruce McEwen, The Rockefeller University, New York, NY, and approved August 14, 2018 (received for review April 6, 2018)
Significance
Understanding
how stress predisposes for psychopathology requires the identification
of physiological stress-regulatory mechanisms with pathogenic potential.
Here, we applied fMRI to investigate the interaction between acute
psychosocial stress and the brain’s hemodynamic response function (HRF).
The HRF models how local neural activity elicits cerebral blood flow
changes, spanning several biophysical processes including neurovascular
coupling (NVC). Stress replicably shifted the HRF peak in temporal,
insular, and prefrontal brain regions, moderated by functional variants
of KCNJ2, a protein involved in NVC. Hippocampal HRF markers
correlated with the cortisol response and genetic variants that reflect
transcriptional responses to glucocorticoids and the risk for
depression. We suggest that acute psychosocial stress modulates
hemodynamic response properties which could lead to previously
undescribed endophenotypes of stress-related disorders.
Abstract
Ample
evidence links dysregulation of the stress response to the risk for
psychiatric disorders. However, we lack an integrated understanding of
mechanisms that are adaptive during the acute stress response but
potentially pathogenic when dysregulated. One mechanistic link emerging
from rodent studies is the interaction between stress effectors and
neurovascular coupling, a process that adjusts cerebral blood flow
according to local metabolic demands. Here, using task-related fMRI, we
show that acute psychosocial stress rapidly impacts the peak latency of
the hemodynamic response function (HRF-PL) in temporal, insular, and
prefrontal regions in two independent cohorts of healthy humans. These
latency effects occurred in the absence of amplitude effects and were
moderated by regulatory genetic variants of KCNJ2, a known
mediator of the effect of stress on vascular responsivity. Further,
hippocampal HRF-PL correlated with both cortisol response and genetic
variants that influence the transcriptional response to stress hormones
and are associated with risk for major depression. We conclude that
acute stress modulates hemodynamic response properties as part of the
physiological stress response and suggest that HRF indices could serve
as endophenotype of stress-related disorders.
Footnotes
- ↵1To whom correspondence should be addressed. Email: saemann@psych.mpg.de.
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