So the advisors to this dissertation candidate should followup with human research testing this out. That is the minimum a competent university department should be doing.
Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
2018, Master of Science (MS), Wright State University, Microbiology and Immunology.
Stroke
is the leading cause of long-term disability and 87% of all strokes are
due to ischemic strokes. In this current study, we examined whether
voluntary physical rehabilitation can influence neurogenesis (measured
by Doublecortin) in the subventricular zone and show improved motor
functional recovery in 10-12 month female rats after ischemia. We saw a
significant increase in the neurogenesis (measured by doublecortin) of
all three regions (anterior, middle and posterior) of SVZ in the rehab
animals compared to control group when using a two-way variance ANOVA
test, although we were unable to see significant differences in paired
t-tests of similar regions for control and rehab animals. The control
animals showed a significant increase in contralateral functional
recovery of 56% with rehab animals displaying a recovery of 23%. These
findings suggest that the physical rehabilitation showed increased
neurogenesis in the SVZ but did not translate to greater contralateral
functional recovery.
Adrian M. Corbett, Ph.D. (Committee Chair)
Nancy J. Bigley, Ph.D. (Committee Member)
Debra Ann Mayes, Ph.D. (Committee Member)
Nancy J. Bigley, Ph.D. (Committee Member)
Debra Ann Mayes, Ph.D. (Committee Member)
88 p.
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