Deans' stroke musings: Longitudinal Functional Brain Mapping in Supernormals

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, December 22, 2018

Longitudinal Functional Brain Mapping in Supernormals

There is no one in the world that I can go to to give me protocols to assure I become a supernormal. At age 90+ I still want to have all the social connections and drinking I do right now. Along with much international travel. For me, 8 days in Ecuador in Jan., 16 days in Italy in Feb.-Mar. 6 days in London in March. I'm sure there will be more for the rest of the year.

Longitudinal Functional Brain Mapping in Supernormals

Xixi Wang Ping Ren Timothy M Baran Rajeev D S Raizada Mark Mapstone Feng Lin the Alzheimer’s Disease Neuroimaging Initiative

Cerebral Cortex, Volume 29, Issue 1, 1 January 2019, Pages 242–252, https://doi.org/10.1093/cercor/bhx322

Published:

23 November 2017

Article history

Abstract

Prevention of age-related cognitive decline is an increasingly important topic. Recently, increased attention is being directed at understanding biological models of successful cognitive aging. Here, we examined resting-state brain regional low-frequency oscillations using functional magnetic resonance imaging in 19 older adults with excellent cognitive abilities (Supernormals), 28 older adults with normative cognition, 57 older adults with amnestic mild cognitive impairment, and 26 with Alzheimer’s disease. We identified a “Supernormal map”, a set of regions whose oscillations were resistant to the aging-associated neurodegenerative process, including the right fusiform gyrus, right middle frontal gyrus, right anterior cingulate cortex, left middle temporal gyrus, left precentral gyrus, and left orbitofrontal cortex. The map was unique to the Supernormals, differentiated this group from cognitive average-ager comparisons, and predicted a 1-year change in global cognition (indexed by the Montreal Cognitive Assessment scores, adjusted R² = 0.68). The map was also correlated to Alzheimer’s pathophysiological features (beta-amyloid/pTau ratio, adjusted R² = 0.66) in participants with and without cognitive impairment. These findings in phenotypically successful cognitive agers suggest a divergent pattern of brain regions that may either reflect inherent neural integrity that contributes to Supernormals’ cognitive success, or alternatively indicate adaptive reorganization to the demands of aging.