Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, December 20, 2018

Neuroprotective effect of Bacopa monniera on ischemia induced brain injury

Well nothing will ever be done for testing in humans. There is NO STROKE LEADERSHIP to talk to and NO STROKE STRATEGY.  Besides there have been 1000+ failures in trying neuroprotection therapies that worked in rodents that didn't work in humans. And no one has ever figured out why, so this is also destined to fail in humans. 

 

Neuroprotective effect of Bacopa monniera on ischemia induced brain injury


Abstract

Purpose

Brain stroke is a leading cause of death without effective treatment. B. monniera, an Indian herbal medicine, exerts antioxidant activity and antistress activity by modulating the antioxidative defence system. We wanted to test if B. monniera could alleviate the ischemia induced brain injury and cognitive dysfunction in Wistar rats.

Procedure

We studied the effect of B. monniera (120 mg kg− 1, 160 mg kg− 1 and 240 mg kg− 1 P.O.) on transient intracarotid artery (ICA) occlusion induced ischemia by testing the neurobehavioral and biochemical parameters on treated and control rats.

Findings

B. monniera attenuated the reduced transfer latency in ischemic rats in a step through test and showed a protective effect on ischemia induced memory impairment in the plus maze task. It also showed a marginal improvement in neurodeficit score and fore limb muscle grip strength. B. monniera reduced the infarct size in the ischemic brain. It also decreased nitrite, nitrate and lipid peroxidation and significantly improved catalase activity.

Conclusion

These observations suggest the neuroprotective and antioxidant activity of B. monniera on ischemia induced brain injury and pave the way for future investigations.

Research Highlights

►We studied the effect of B. monniera on transient intracarotid artery (ICA) occlusion induced ischemia. ►B. monniera attenuated ischemia induced brain injury. ►It also reversed impaired neurobehavioral and biochemical parameters in rats. ►This study observation suggests the neuroprotective and antioxidant activity of B. monniera.
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1 comment:

  1. DeniseDecember 30, 2018 at 3:27 PM

    I've actually been taking bacopa (a supplement I get on Amazon) for 3 years now. I'm sure I'm doing it all wrong, though, I had a hemorrhagic stroke, for one thing, they only looked at people who had ischemic stroke. But I read on Dave Asprey's site that it was helpful for memory (he said he uses it), and figured I can use all the help I can get. I tried it, it does help my memory, I keep using it.

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