You can ask your doctors if anything here would help in stroke recovery. Doesn't know, then the correct and only answer is for them to contact researchers to get an answer. Not doing anything, call the president and ask what the fuck is the responsibility of the stroke doctors. Delivering the status quo of stroke rehab means that the stroke president also needs to be fired. Or you could look up these:
- progesterone (11)
- omega-3 (77)
- vitamin D3 (5)
- glutamine (2)
Combination therapy with vitamin D3, progesterone, omega-3 fatty acids and glutamine reverses coma and improves clinical outcomes in patients with severe traumatic brain injuries: A case series
| How to cite this article: |
| Matthews LR, Danner OK, Ahmed YA, Dennis-Griggs DM, Frederick A, Clark C, Moore R, DuMornay W, Childs EW, Wilson KL. Combination therapy with vitamin d3, progesterone, omega 3-fatty acids and glutamine reverses coma and improves clinical outcomes in patients with severe traumatic brain injuries: A case series. International Journal of Case Reports and Images 2012;4(3):143–149. |
| Abstract
|
| Introduction:
Traumatic brain injury (TBI) is a major public health problem and a
leading cause of death and disability in the United States. Management
of patients with TBI has changed very little over the last 20 years.
Case Series: A case series of three patients with severe TBIs who were aggressively treated with vitamin D3, progesterone, omega 3-fatty acids, and enteral glutamine for six weeks, termed neuroceutical augmentation for traumatic brain injury (NATBI), with very favorable outcomes. Conclusion: A large clinical study trial using these four supplements (NATBI) together is warranted. | |
| Keywords:
Traumatic brain injury, Vitamin D3, Omega-3 fatty acids, Loveza, Progesterone, Cerebral edema, Glutamine
| |
| Introduction
|
| Traumatic brain injury (TBI) is a major public health problem.
According to CDC it affects over 1.7 million people annually in U.S.
with 275,000 hospitalizations and 52,000 deaths. [1] The medical cost for treating TBI patients in the United States in 2010 was $76.5 billion and rising annually. [1]
Primary causes for TBI include the following: motor vehicle crashes,
falls, assaults and sports or recreation-related injuries (concussions).
Finding the right treatment to reduce mortality rates and improve the
clinical outcomes in TBI patients has been elusive. Management of patients with TBI has changed very little over the last 20 years. Advancements in the treatment of TBI requires great understanding of the biochemical mechanisms of the brain during a normal resting state as well as the metabolism after a severe traumatic event. Brain metabolism is markedly altered during TBI. After the initial insult to the brain, the brain's metabolism is altered and can increase up to 140% of its normal metabolism. Vitamin D (a steroid hormone) and omega-3 fatty acids (an essential fatty acid) are both very powerful anti-inflammatory agents that reduce cerebral edema and swelling. Glutamine becomes an essential amino acid during stress and produces the extra glucose (via the Cori cycle) that is used by the injured brain and the extra glucose used by the immune response system to fight off infection during stress. Progesterone (also a steroid hormone) is a neuroprotector of injured brain cells and potentiates the effect of vitamin D. These agents are all immune modulators which work synergistically to prevent secondary brain injury by limiting or decreasing inflammation; an increasing well-recognized cause of ongoing brain swelling after a primary injury. They are also neuroprotectors that makes the neurons more resistant to stress, ischemia, hypothermia, hyperthermia, hypoglycemia, hyperglycemia, hypotension, and hypertension. Immune modulation with nutritional supplements is a rapidly advancing field with a very promising future in treating TBI as well as other critically injured/ill patients. We present a case series of three patients with severe TBIs who were aggressively treated with vitamin D3, progesterone, omega-3 fatty acids and enteral glutamine for up to six weeks, termed neuroceutical augmentation for traumatic brain injury (NATBI), with very favorable outcomes. [2] [3] [4] [5] Patients in a coma with severe TBI (Glascow Coma Score <8) who were admitted to a Level I trauma center were evaluated in a prospective observational study. Patients were treated with a neuroceutical combination of vitamin D3, omega-3 fatty acids, progesterone, and glutamine initially via a nasogastric tube and later orally for six weeks. Primary outcomes were mortality rate and return to recovery which was defined as a Glascow Coma Score (GCS) of 10 or greater.NATBI protocol works on multiple levels and neuroprotective pathways in TBI patients by down regulating cytokine production, preventing oxidative stress (free radical oxygen formation), decreasing cerebral edema, and inflammation, thus limiting secondary brain injury in contradistinction to progesterone therapy alone (Protect III study). [3] [4] [5] In addition, our NATBI regimen is relatively inexpensive, safe, and very effective at reducing brain and systemic inflammation post-injury. |
| Leslie R Matthews1, Omar K Danner1, Y A Ahmed2, Diane M Dennis-Griggs1, Alexis Frederick1, Clarence Clark1, Ronald Moore1, Wilson DuMornay1, Ed W Childs1, Kenneth L Wilson1 | ||||||
| 1Morehouse School of Medicine, Department of Surgery, 720 Westview Drive, SW, Atlanta, GA, USA.
2Department of Epidemiology, King Saud University, College of Pharmacy, Riyadh, Kingdom of Saudia of Arabia. | ||||||
| ||||||
| [HTML Abstract]
[PDF Full Text]
[Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar] 
|
No comments:
Post a Comment