Well shit, this is probably based on this earlier research. Is it the gas used inside the bubbles rather than the ultrasound? Maybe this:the xenon gas in the bubbles.
Historic breakthrough: WVU Rockefeller Neuroscience team first to use ultrasound to treat Alzheimer's
MORGANTOWN — World-leading brain experts at West Virginia University’s Rockefeller Neuroscience Institute are celebrating the historic breakthrough Alzheimer patients around the globe have been awaiting.
“For Alzheimer’s, there’s not that many treatments available, despite hundreds of clinical trials over the past two decades and billions of dollars spent,” said Dr. Ali R. Rezai, a neurosurgeon at WVU who led the team of investigators that successfully performed a phase II trial using focused ultrasound to treat a patient with early stage Alzheimer’s.
The WVU team tested the innovative treatment in collaboration with INSIGHTEC, an Israeli medical technology company. Earlier this year, INSIGHTEC was approved by the U.S. Food and Drug Administration to begin a phase II clinical trial of the procedure, and selected the WVU Rockefeller Neuroscience Institute as the first site in the United States for that trial.
Last summer, researchers at Sunnybrook Health Sciences Centre in Toronto reported the results of a phase I safety trial showing they could reversibly open the blood-brain barrier in Alzheimer’s patients.
“And when we put a different frequency of ultrasound on the bubbles, they start oscillating,” he said.
The reaction opens up the brain-blood barrier — a nearly impenetrable shield between the brain’s blood vessels and cells that make up brain tissue.
“It’s protected on one end for us to function but also prevents larger molecules or chemotherapy or medications or anti-bodies or immune system cells or amino therapy or stem cells to get in,” he said.
In this case, the West Virginia team targeted the hippocampus and the memory and cognitive centers of the brain that are impacted by plaques found in patients with Alzheimer’s.
“Plaques are these clusters of proteins that accumulate and they block-up the brain’s connectivity,” he said. “In animal studies it showed that these plaques are cleared with ultrasound technology.
The first patient, a person Rezai called a pioneer and hero, is West Virginia health care worker and former WVU Children’s Hospital Neonatal Intensive Care Unit nurse Judi Polak.
“I think that with Alzheimer’s there’s so much in the unknown and I’ve been with H
ealth Science for a long time and I understand that we need to be able to step forward and look into the future,” Polak said.
But getting to this point was a long journey beginning five years ago when she was first diagnosed with early-onset Alzheimer’s.
“That took me a while to deal with,” Polak admitted while sitting with her husband of 36 years, Mark Polak. “It was hard to say that I have Alzheimer’s. I didn’t want to be the person who felt sorry for myself and so we looked at clinical trials as a way to help not only me but other people too.”
Early-onset Alzheimer’s is an uncommon form of dementia that strikes people younger than age 65. Of all the people who have Alzheimer’s disease, according to research conducted by the Mayo Clinic, about 5 percent develop symptoms before age 65.
Judi Polak’s willingness to be the center of a study or research experiment in hopes of finding a cure for Alzheimer’s took an emotional toll, Mark Polak said, referring to a controlled drug-placebo trial at the University of Pittsburgh several years ago.
Guess what, the drug didn’t work,” he said with contempt. “Just like every drug that has been tried doesn’t work.”
However, Judi Polak’s patience and persistence appears to have paid off. The procedure, which lasted three hours, safely and successfully opened her blood-brain barrier for a record 36 hours.
“It was opened longer than they expected,” Mark Polak said. “They were actually, I think both excited and scared. The team was ecstatic.”
One member of the team Mark Polak mentioned is Dr. Jeff Carpenter, a professor of neurology, neurosurgery and an interventional neuroradiologist at WVU.
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