Introduction
Stroke is the fifth leading cause of death in the United States and a significant cause of severe disability in adults.1 Each year, around 800,000 Americans experience a new or recurrent stroke.2
Rapid diagnosis and treatment of stroke is crucial and leads to
improved outcomes and prognosis among patients treated within the
‘Golden Hour’.3,4
However, strokes, especially posterior circulation strokes, are associated with significant (>10%) diagnostic error.5
The latter could be due to (1) some patients with acute stroke present
with non-focal symptoms such as dizziness, diplopia, dysarthria, or
ataxia,6
which may not trigger a neurology consult or a need for a more detailed
neurological examination; (2) stroke is commonly misdiagnosed in
younger patients7,8;
and (3) the emergency department (ED) is a challenging environment for
providers, especially with the multiplicity of care protocols, and the
dynamic nature of patient care.8,9
Triage, consultations, admissions, discharge, and other steps in
emergency care are time-sensitive, complex, and always changing to
further improve efficacy and quality of care. Therefore, identifying
potential stroke symptoms can be challenging,10–12 especially when the providers are in training.13,14 Besides, the risk of misdiagnosis can be higher among walk-in patients,15 when the providers do not receive a pre-arrival notification from emergency medical services,16 or when a neurologist is not readily available for an urgent consultation.17–19
Scoring systems for the diagnosis of stroke and recurrent stroke do not
have a high sensitivity to diagnose the posterior circulation stroke.20,21
Furthermore, these tools are also not automatic, and require that the
physicians suspect stroke as a differential diagnosis to apply the
scoring system.
Artificial intelligence (AI), a computational
framework meaning to emulate human insight, is one of the most
transformative technologies.22,23
The era of augmented intelligence in healthcare is driven by the notion
that intelligent algorithms can support providers in diagnosis,
treatment, and outcome prediction, especially with growing digital and
connected patient data and advances in computational abilities.24–26
The augmented-diagnostic model for stroke may be particularly helpful
in low volume or non-stroke centers’ ED, where emergency providers have
limited daily exposure to stroke. An automated, computer-assisted
screening tool that can be seamlessly integrated into clinical workflow
to quickly analyze patient symptoms and clinical data and suggest a
diagnosis of stroke (‘StrokeAlert’ pop-up) in an ED setting could be
valuable. Such a system will also help bring access and timely diagnosis
for patients who choose to self-present to an ED. In this paper, we
present a practical framework and summarize the stages needed to create a
machine learning (ML)-enabled clinical decision support system for the
screening of stroke patients in ED using data from electronic health
records (EHRs) combined with the patient’s presenting symptoms at the
point of care. We have assembled a team of experts and are leading such
effort at Geisinger. Figure 1 summarizes the key steps of such a system.
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