Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, July 7, 2021

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

 But this has been known for years, isn't your doctor already prescribing psilocybin for you?

Psilocybin: Magic mushrooms have been found to boost neurogenesis. August 2013

Psilocybin induces time-dependent changes in global functional connectivity: Psi-induced changes in brain connectivity February 2020 

The latest here:

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Published:July 05, 2021DOI:https://doi.org/10.1016/j.neuron.2021.06.008

Highlights

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    Psilocybin ameliorates stress-related behavioral deficit in mice
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    Psilocybin increases spine density and spine size in frontal cortical pyramidal cells
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    Psilocybin-evoked structural remodeling is persistent for at least 1 month
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    The dendritic rewiring is accompanied by elevated excitatory neurotransmission

Summary

Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and timescale of the impact in a mammalian brain are unknown. In this study, we used chronic two-photon microscopy to image longitudinally the apical dendritic spines of layer 5 pyramidal neurons in the mouse medial frontal cortex. We found that a single dose of psilocybin led to ∼10% increases in spine size and density, driven by an elevated spine formation rate. The structural remodeling occurred quickly within 24 h and was persistent 1 month later. Psilocybin also ameliorated stress-related behavioral deficit and elevated excitatory neurotransmission. Overall, the results demonstrate that psilocybin-evoked synaptic rewiring in the cortex is fast and enduring, potentially providing a structural trace for long-term integration of experiences and lasting beneficial actions.

Graphical abstract

Figure thumbnail fx1

Keywords

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