Will you stop predicting failure to recover and CREATE EXACT STROKE PROTOCOLS THAT PRODUCE MOTOR RECOVERY? Do you not understand the only goal in stroke? 100% recovery! This does nothing for that. Your mentors and senior researchers need to get remedial training in stroke.
Machine Learning for Predicting Motor Improvement After Acute Subcortical Infarction Using Baseline Whole Brain Volumes
Abstract
Background.
Neuroimaging biomarkers are valuable predictors of motor improvement
after stroke, but there is a gap between published evidence and clinical
usage. (Absolute bullshit,biomarkers are useless, just used to justify your doctor's failure to get you recovered. The status quo is a complete failure and your doctor is not penalized for letting failure continue for decades.)
Objective.
In this work, we aimed to investigate whether machine learning techniques, when applied to a combination of baseline whole brain volumes and clinical data, can accurately predict individual motor outcome after stroke.
Methods.
Upper extremity Fugl-Meyer Assessments (FMA-UE) were conducted 1 week and 12 weeks, and structural MRI was performed 1 week, after onset in 56 patients with subcortical infarction. Proportional recovery model residuals were employed to assign patients to proportional and poor recovery groups (34 vs 22). A sophisticated machine learning scheme, consisting of conditional infomax feature extraction, synthetic minority over-sampling technique for nominal and continuous, and bagging classification, was employed to predict motor outcomes, with the input features being a combination of baseline whole brain volumes and clinical data (FMA-UE scores).
Results.
The proposed machine learning scheme yielded an overall balanced accuracy of 87.71% in predicting proportional vs poor recovery outcomes, a sensitivity of 93.77% in correctly identifying poor recovery outcomes, and a ROC AUC of 89.74%. Compared with only using clinical data, adding whole brain volumes can significantly improve the classification performance, especially in terms of the overall balanced accuracy (from 80.88% to 87.71%) and the sensitivity (from 92.23% to 93.77%).
Conclusions.
Experimental results suggest that a combination of baseline whole brain volumes and clinical data, when equipped with appropriate machine learning techniques, may provide valuable information for personalized rehabilitation planning after subcortical infarction.
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