This just completely and totally proves that stroke has no strategic plan with the existing medical team. They all need to be fired and we need to start over with stroke-addled survivors. We can't do any worse than supposedly healthy brain normal people.
https://stroke.ahajournals.org/content/26/1/117.full
- Stuart E. Smith, MSc, PhD;
- Brian S. Meldrum, MB, BChir, PhD
+ Author Affiliations
- Correspondence to B.S. Meldrum, Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, UK.
Abstract
Background and Purpose Glutamate
receptor antagonists are protective in animal models of focal cerebral
ischemia. Lamotrigine
(3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine)
is an anticonvulsant drug that blocks
voltage-gated sodium channels and inhibits the ischemia-induced release
of glutamate.
We describe the cerebroprotective effect of
lamotrigine (as the isethionate salt) after middle cerebral artery
occlusion in
rats.
Methods Neurological deficit
and infarct volume (visualized by the lack of reduction of
2,3,5-triphenyltetrazolium chloride) 24 hours
after permanent left middle cerebral artery
occlusion were studied in Fischer rats (n=8 per group per dose).
Results Lamotrigine at 20
mg/kg IV over 10 minutes administered immediately after middle cerebral
artery occlusion reduced total infarct
volume by 31% and cortical infarct volume by
52%. Lamotrigine at 8 mg/kg IV over 10 minutes reduced cortical infarct
volume
by 38%. Lamotrigine at 50 mg/kg IV for 10
minutes was not cerebroprotective and induced a decrease of 29±15 mm Hg
in mean
arterial blood pressure (P<.05,
n=8). The optimum dose of lamotrigine (20 mg/kg IV over 10 minutes) when
administered with a 1-hour delay after middle
cerebral artery occlusion reduced cortical
infarct volume by 41%. Lamotrigine (20 mg/kg IV over 10 minutes) with a
2-hour
delay after middle cerebral artery occlusion was
ineffective. Neurological deficits after 24 hours were improved after
immediate
treatment with lamotrigine at 20 mg/kg IV over
10 minutes.
Conclusions The cerebroprotective effect of lamotrigine in rats is limited to a narrow dose range between 8 and 20 mg/kg. Lamotrigine
or analogous compounds may be useful when given shortly after the onset of stroke.
Lamotrigine at 20 mg a kg could cause trouble. They have to start slow and increase the dose every several days. Interesting though. Jim`s been on it since about week 5 post. Just a thought as to why they don`t use it. The dextromethorphan(cough syrup) and/or ginger might help in reducing the glutamate. Ruth
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