Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 18, 2014

Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats

It has only been 19 f*cking years. Has anyone followed this up with human trials?
This just completely and totally proves that stroke has no strategic plan with the existing medical team. They all need to be fired and we need to start over with stroke-addled survivors. We can't do any worse than supposedly healthy brain normal people.
https://stroke.ahajournals.org/content/26/1/117.full
  1. Brian S. Meldrum, MB, BChir, PhD
+ Author Affiliations
  1. From the Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, UK.
  1. Correspondence to B.S. Meldrum, Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, UK.

Abstract

Background and Purpose Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the cerebroprotective effect of lamotrigine (as the isethionate salt) after middle cerebral artery occlusion in rats.
Methods Neurological deficit and infarct volume (visualized by the lack of reduction of 2,3,5-triphenyltetrazolium chloride) 24 hours after permanent left middle cerebral artery occlusion were studied in Fischer rats (n=8 per group per dose).
Results Lamotrigine at 20 mg/kg IV over 10 minutes administered immediately after middle cerebral artery occlusion reduced total infarct volume by 31% and cortical infarct volume by 52%. Lamotrigine at 8 mg/kg IV over 10 minutes reduced cortical infarct volume by 38%. Lamotrigine at 50 mg/kg IV for 10 minutes was not cerebroprotective and induced a decrease of 29±15 mm Hg in mean arterial blood pressure (P<.05, n=8). The optimum dose of lamotrigine (20 mg/kg IV over 10 minutes) when administered with a 1-hour delay after middle cerebral artery occlusion reduced cortical infarct volume by 41%. Lamotrigine (20 mg/kg IV over 10 minutes) with a 2-hour delay after middle cerebral artery occlusion was ineffective. Neurological deficits after 24 hours were improved after immediate treatment with lamotrigine at 20 mg/kg IV over 10 minutes.
Conclusions The cerebroprotective effect of lamotrigine in rats is limited to a narrow dose range between 8 and 20 mg/kg. Lamotrigine or analogous compounds may be useful when given shortly after the onset of stroke.

1 comment:

  1. Lamotrigine at 20 mg a kg could cause trouble. They have to start slow and increase the dose every several days. Interesting though. Jim`s been on it since about week 5 post. Just a thought as to why they don`t use it. The dextromethorphan(cough syrup) and/or ginger might help in reducing the glutamate. Ruth

    ReplyDelete