What does your doctor have to say about this?
Can coenzyme Q10 reduce the risk of side effects from statins?
Or is this atherosclerosis inhibition a better reason for it?
Coenzyme Q10 Increases Cholesterol Efflux and Inhibits Atherosclerosis Through MicroRNAs
+ Author Affiliations
- Correspondence to Kasey C. Vickers, PhD, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Ave 312B PRB, Nashville, TN 37232. E-mail kasey.c.vickers@vanderbilt.edu
Atherosclerosis is a progressive
inflammatory disease of the artery wall and the underlying basis for
cardiovascular disease
(CVD), which accounts for ≈32% of all deaths in
the United States and is the leading cause of mortality in the world.1
Atherosclerosis is classically defined by the accumulation of lipid and
cholesterol deposits within the subendothelial space
in the artery wall which leads to chronic
inflammation and proinflammatory, cholesterol-laden macrophages which
differentiate
into resident foam cells in the lesion,
ultimately forming an acellular necrotic core.2
To date, the statin drug class has been overwhelmingly successful at
reducing circulating total cholesterol levels, namely
low-density lipoproteins cholesterol, the number
one risk factor for CVD. Although pharmacological intervention with
statins
has dramatically reduced the number of
cardiovascular events, many patients do not tolerate statins and a
substantial disease
burden remains even in patients who are on
statins. Therefore, a great need remains to identify new drug targets
and novel
approaches to prevent and treat atherosclerosis
and CVD. One strategy that has been extensively studied, but remains
central
to atherosclerosis reduction, is identifying new
ways to increase the removal of excess cholesterol from peripheral
cells
and lesions through the reverse cholesterol
transport (RCT) pathway. Briefly, the RCT pathway involves the transport
of cholesterol
from peripheral tissues (ie, foam cells within
atherosclerotic lesions) to the liver by high-density lipoproteins
(HDL), where
cholesterol is excreted from the body as bile.3 This pathway is mediated by a number of lipid and cholesterol transporters, including the widely …
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