Endogenous neurogenesis following ischaemic brain injury: Insights for therapeutic strategies

Ask your doctor to create a translational research project with other doctors to figure out what the standard stroke protocol should be for this. They will not do this on their own. YOU have to initiate this and create the expectation that they will follow thru.
If we had a great stroke association it could be handed off to them and the project would get done. But we have press release stroke associations. I don't know how the boards of directors can live with themselves for such pathetic efforts.
http://www.sciencedirect.com/science/article/pii/S1357272514002544

• Tobias D. Merson^{a, b, ,} ,
• James A. Bourne^{c, , ,}

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DOI: 10.1016/j.biocel.2014.08.003

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Abstract

Ischaemic stroke is among the most common yet most intractable types of central nervous system (CNS) injury in the adult human population. In the acute stages of disease, neurons in the ischaemic lesion rapidly die and other neuronal populations in the ischaemic penumbra are vulnerable to secondary injury. Multiple parallel approaches are being investigated to develop neuroprotective, reparative and regenerative strategies for the treatment of stroke. Accumulating evidence indicates that cerebral ischaemia initiates an endogenous regenerative response within the adult brain that potentiates adult neurogenesis from populations of neural stem and progenitor cells. A major research focus has been to understand the cellular and molecular mechanisms that underlie the potentiation of adult neurogenesis and to appreciate how interventions designed to modulate these processes could enhance neural regeneration in the post-ischaemic brain. In this review, we highlight recent advances over the last 5 years that help unravel the cellular and molecular mechanisms that potentiate endogenous neurogenesis following cerebral ischaemia and are dissecting the functional importance of this regenerative mechanism following brain injury.

This article is part of a Directed Issue entitled: Regenerative Medicine: the challenge of translation.

Keywords

• Stroke;
• Neural stem cells;
• Cell proliferation;
• Brain repair;
• Cell signalling

☆

This article is part of a Directed Issue entitled: Regenerative Medicine: the challenge of translation.

Corresponding author at: Florey Institute of Neuroscience and Mental Health, Kenneth Myer Building, 30 Royal Parade, Parkville, VIC 3010, Australia. Tel.: +61 3 90356535; fax: +61 3 86779826.

Corresponding author. Tel.: +61 3 99029622; fax: +61 3 99052766.

Copyright © 2014 Published by Elsevier Ltd.

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