I assume post-stroke we do want artery dilatation. So is this in your post-stroke hospital diet? Can your doctor use enough brains to see if this would work even in non-smokers? Do not do this without your doctors prescription. You know how damned dangerous dark chocolate is.
NOX2-mediated artery dysfunction in smokers: acute effect of dark chocolate
- Lorenzo Loffredo,
- Roberto Carnevale,
- Ludovica Perri,
- Elisa Catasca,
- Teresa Augelletti,
- Roberto Cangemi,
- Fabiana Albanese,
- Cristina Piccheri,
- Cristina Nocella,
- Pasquale Pignatelli,
- Francesco Violi
+ Author Affiliations
- Correspondence to Professor Francesco Violi, I Clinica Medica, Viale del Policlinico 155, Roma 00161, Italy; francesco.violi@uniroma1.it
-
Contributors Conception and design: FV, LL. Analysis and interpretation of data: FV, LL, RC, PP. Flow-mediated dilation analysis: LL. Patient enrolment: LP, EC, TA, RC, FA. Laboratory analysis: RC, CN, CP. Drafting the article: FV, LL.
- Accepted 30 June 2011
- Published Online First 31 July 2011
Abstract
Background Cocoa seems to exert artery dilatation via oxidative stress inhibition but the mechanism is still unclear.
Objectives To investigate whether in smokers, dark chocolate elicits artery dilatation via down-regulation of NOX2, the catalytic core
of NADPH oxidase.
Methods
Flow-mediated dilatation (FMD), oxidative stress (as assessed by urinary
isoprostanes excretion), nitric oxide generation
(as assessed by serum levels of
nitrite/nitrate (NOx)), NOX2 activity (as assessed by blood levels of
soluble NOX2 derived
peptide (sNOX2-dp)) and serum
epicatechin were studied in 20 smokers and 20 healthy subjects (HS) in a
crossover, single-blind
study. Patients were randomly
allocated to 40 g dark chocolate (>85% cocoa) or 40 g of milk
chocolate (≤35% cocoa). FMD, urinary
isoprostanes, NOx and sNOX2-dp were
assessed at baseline and 2 h after chocolate ingestion.
Results
Smokers had lower FMD and NOx and higher sNOX2-dp compared to HS. After
dark chocolate intake, urinary isoprostanes and sNOX2-dp
significantly decreased and FMD and
NOx significantly increased in smokers but not in HS. No changes of the
above variables
were observed after milk chocolate
intake. Multiple linear regression analysis showed that in smokers the
only independent
predictive variable associated with a
change in FMD was a change in sNOX2-dp. Serum epicatechin increased in
either group
only after dark chocolate intake,
reaching values higher than 0.1 μM. Platelets from smokers (n=5), but
not from HS (n=5),
showed lower p47phox translocation to platelet membrane and higher NOx when incubated with 0.1–10 μM epicatechin.
Conclusion Results suggest that in smokers, cocoa enhances artery dilatation by lowering of NOX2 activation.
You're recommending that people eat chocolate? How dare you! Have you no decency???
ReplyDeleteAmy, you will notice I recommended a doctors prescription for this. I wouldn't presume to know more than our incredibly stupid doctors.
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