Deans' stroke musings: Resting-state functional connectivity in anterior cingulate cortex in normal aging

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, November 26, 2014

Resting-state functional connectivity in anterior cingulate cortex in normal aging

Ask your doctor to compare your brain connectivity post-stroke to what is normal at your age and if any deficits are found propose a stroke protocol to correct them. Your doctor has no stroke protocols and has no idea what this means? Why the hell are you seeing such as worthless doctor?
But don't listen to me, as a non-medical stroke-addled person I can have no coherent thoughts on what the fucking hell is wrong with stroke rehabilitation. Does your doctor have a single coherent thought on stroke rehab? I dare you to challenge your doctor to explain exactly how you are going to 100% recover. No excuses from your doctor.
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00280/full?

Weifang Cao¹,

Cheng Luo¹^*,

Bin Zhu¹,

Dan Zhang¹,

Li Dong¹,

Jinnan Gong¹,

Diankun Gong¹,

Hui He¹,

Shipeng Tu¹,

Wenjie Yin²,

Jianfu Li¹,

Huafu Chen¹ and

Dezhong Yao¹^*

¹The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu, China
²Radiology Department, Chengdu First People's Hospital, Chengdu, China

Growing evidence suggests that normal aging is associated with cognitive decline and well-maintained emotional well-being. The anterior cingulate cortex (ACC) is an important brain region involved in emotional and cognitive processing. We investigated resting-state functional connectivity (FC) of two ACC subregions in 30 healthy older adults vs. 33 healthy younger adults, by parcellating into rostral (rACC) and dorsal (dACC) ACC based on clustering of FC profiles. Compared with younger adults, older adults demonstrated greater connection between rACC and anterior insula, suggesting that older adults recruit more proximal dACC brain regions connected with insula to maintain a salient response. Older adults also demonstrated increased FC between rACC and superior temporal gyrus and inferior frontal gyrus, decreased integration between rACC and default mode, and decreased dACC-hippocampal and dACC-thalamic connectivity. These altered FCs reflected rACC and dACC reorganization, and might be related to well emotion regulation and cognitive decline in older adults. Our findings provide further insight into potential functional substrates of emotional and cognitive alterations in the aging brain.