FIX that!!!
http://stroke.ahajournals.org/content/44/11/3044.abstract
- Peter Langhorne, PhD;
- Patricia Fearon, MBChB;
- Ole M. Ronning, MD;
- Markku Kaste, MD;
- Heikki Palomaki, MD;
- Kostos Vemmos, MD;
- Lalit Kalra, MD;
- Bent Indredavik, MD;
- Christian Blomstrand, MD;
- Helen Rodgers, MBChB;
- Martin S. Dennis, MD;
- Rustam Al-Shahi Salman, MD
- on behalf of the Stroke Unit Trialists’ Collaboration
+ Author Affiliations
- Correspondence to Peter Langhorne, PhD, Academic Section of Geriatric Medicine, Level 4, Walton Building, Royal Infirmary, Glasgow G4 0SF, United Kingdom. E-mail Peter.Langhorne@glasgow.ac.uk
Abstract
Background and Purpose—Patients
with any type of stroke managed in organized inpatient (stroke unit)
care are more likely to survive, return home,
and regain independence. However, it is
uncertain whether these benefits apply equally to patients with
intracerebral hemorrhage
and ischemic stroke.
Methods—We
conducted a secondary analysis of a systematic review of controlled
clinical trials comparing stroke unit care with general
ward care, including only trials published
after 1990 that could separately report outcomes for patients with
intracerebral
hemorrhage and ischemic stroke. We performed
random-effects meta-analyses and tested for subgroup interactions by
stroke type.
Results—We
identified 13 trials (3570 patients) of modern stroke unit care that
recruited patients with intracerebral hemorrhage and
ischemic stroke, of which 8 trials provided
data on 2657 patients. Stroke unit care reduced death or dependency
(risk ratio
[RR], 0.81; 95% confidence interval [CI],
0.471–0.92; P=0.0009; I2=60%) with no difference in benefits for patients with intracerebral hemorrhage (RR, 0.79; 95% CI, 0.61–1.00) than patients
with ischemic stroke (RR, 0.82; 95% CI, 0.70–0.97; Pinteraction=0.77). Stroke unit care reduced death (RR, 0.79; 95% CI, 0.64–0.97; P=0.02; I2=49%) to a greater extent for patients with intracerebral hemorrhage (RR, 0.73; 95% CI, 0.54–0.97) than patients with ischemic
stroke (RR, 0.82; 95%, CI 0.61–1.09), but this difference was not statistically significant (Pinteraction=0.58).
Conclusions—Patients
with intracerebral hemorrhage seem to benefit at least as much as
patients with ischemic stroke from organized inpatient
(stroke unit) care.
No comments:
Post a Comment