When is someone in charge going to take responsibility for pushing stuff like this out to stroke hospitals or create clinical trials to prove this out? Well shit, we have NO ONE in charge, so this will never occur, our stroke associations will not do this, so survivors are once again screwed.
We have no stroke leaders, get used to it.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=153710&CultureCode=en
After 8 weeks new neurons, glia and blood vessels were found
surrounding the scaffold and also inside of the synthetic structure
based on a ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA). This
regenerative process did not occur in areas where the scaffold was not
present, nor in non-implanted control animals. Professors at the CEU
Cardenal Herrera University in Valencia have collaborated in this sudy
with researchers from the Universitat Politècnica de València,
Universidad Complutense and Hospital Clínico San Carlos, in Madrid.
Professors from the Faculty of Health Sciences of the CEU Cardenal
Herrera University (CEU-UCH), in Valencia, José Miguel Soria López and
María Ángeles García Esparza, have taken part in a new study in order to
evaluate, in vivo, the biocompatibility and cell hosting ability of a
copolymer channelled scaffold, after an experimental brain injury. This
biomaterial, based on ethyl acrylate (EA) and hydroxyl ethyl acrylate
(HEA), was implanted after focal brain damage in rats, allowing cell
migration, survival and cell colonization by neurons, glial cells, and
endothelial cells, which formed vessel-like neostructures, within the
scaffold.
The professors collaborated with researchers from Universitat
Politècnica de València, Universidad Complutense and Hospital Clínico
San Carlos, in Madrid. The results have been published in Neuroscience
Letters.
According to Professor Soria, head of the Research Group on
neuro-protection and neuro-repair of the central nervous system, at
CEU-UCH, the scaffolds made of this acrylate copolymer were implanted in
the site of a previous cryolesion in the brain of Wistar rats: “We
evaluated the tissue response to the implanted materials after 8 weeks
and we observed that they provoked a minimal scar response by the host
tissue and, also, permitted the invasion of neurons and glia inside
them.” As Professor Soria adds, “this reparative process did not occur
in areas where the scaffold was not present, nor in non-implanted
control animals.”
In this study, “our findings indicate that this copolymer may
constitute an artificial protective niche for the neural cells produced
after injury and migrating from subventricular zone (SVZ) to the site of
the lesion. In the absence of it, the area with the lesion is
irremediably lost. This fact may be of interest for future clinical
applications in the regeneration of injured brain,” says Professor
Soria.
Professor García Esparza, member of this research group at CEU-UCH,
adds: “This copolymer channelled scaffold proves to offer a suitable
environment producing a cellular network potentially useful in brain
repair after brain injury. In our group it is of greatest importance to
identify types of synthetic materials, as a supporting vehicle or
scaffold for the cell population to assist neural regeneration processes
and new angiogenesis, after local brain injury."
http://www.ncbi.nlm.nih.gov/pubmed/25980992
No comments:
Post a Comment