Deans' stroke musings: Interferons as Essential Modulators of Atherosclerosis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, June 24, 2015

Interferons as Essential Modulators of Atherosclerosis

If you have atherosclerosis what is your doctor doing about it?
Do you want the lawnmower?
http://www.articlecity.com/videos/health/Lawnmower-For-Clogged-Arteries-175286465.php
Or Drano? I would be worried about this, sloughing off chunks
http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=26404
Or conventional?
http://video.answers.com/learn-about-coronary-bypass-surgery-286302728

Or maybe something in this latest research?
http://atvb.ahajournals.org/content/35/7/1579.abstract?etoc

+ Author Affiliations

From the Experimental Vascular Biology, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Correspondence to Menno P.J. de Winther, PhD, Experimental Vascular Biology, Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail m.dewinther@amc.uva.nl

Abstract

Interferons (IFNs) are key regulators of both innate and adaptive immune responses. The family of IFN cytokines can be divided into 3 main subtypes of which type I and type II IFNs are most well-defined. IFNs are known to be important mediators in atherosclerosis. Evidence from both in vitro and in vivo studies shows that the IFNs are generally proatherosclerotic. However, their role in atherosclerosis is complex, with distinct roles for these cytokines throughout different stages of the disease. In this review, we will discuss the current knowledge on the role of type I and type II IFNs in atherosclerosis development, specifically focusing on their role in endothelial activation, cell recruitment, foam cell formation, and regulation of apoptosis. Furthermore, we will discuss whether IFNs could be considered as new molecular targets for therapeutic intervention in atherosclerosis.