http://stroke.ahajournals.org/content/early/2015/06/18/STROKEAHA.115.009522.abstract
A Nonrandomized, Parallel-Group, Dosage-Controlled Study
- Jade Dignam, BSpPath,
- David Copland, PhD,
- Eril McKinnon, BSpPath,
- Penni Burfein, BSpPath,
- Kate O’Brien, BSpPath,
- Anna Farrell, PhD and
- Amy D. Rodriguez, PhD
+ Author Affiliations
- Correspondence to Jade Dignam, BSpPath, UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland, 4029 Australia. E-mail j.dignam@uq.edu.au
Abstract
Background and Purpose—Most
studies comparing different levels of aphasia treatment intensity have
not controlled the dosage of therapy provided.
Consequently, the true effect of treatment
intensity in aphasia rehabilitation remains unknown. Aphasia Language
Impairment
and Functioning Therapy is an intensive,
comprehensive aphasia program. We investigated the efficacy of a
dosage-controlled
trial of Aphasia Language Impairment and
Functioning Therapy, when delivered in an intensive versus distributed
therapy schedule,
on communication outcomes in participants
with chronic aphasia.
Methods—Thirty-four
adults with chronic, poststroke aphasia were recruited to participate
in an intensive (n=16; 16 hours per week;
3 weeks) versus distributed (n=18; 6 hours
per week; 8 weeks) therapy program. Treatment included 48 hours of
impairment,
functional, computer, and group-based aphasia
therapy.
Results—Distributed therapy resulted in significantly greater improvements on the Boston Naming Test when compared with intensive
therapy immediately post therapy (P=0.04) and at 1-month follow-up (P=0.002).
We found comparable gains on measures of participants’ communicative
effectiveness, communication confidence, and
communication-related quality of life for the
intensive and distributed treatment conditions at post-therapy and
1-month follow-up.
Conclusions—Aphasia
Language Impairment and Functioning Therapy resulted in superior
clinical outcomes on measures of language impairment
when delivered in a distributed versus
intensive schedule. The therapy progam had a positive effect on
participants’ functional
communication and communication-related
quality of life, regardless of treatment intensity. These findings
contribute to our
understanding of the effect of treatment
intensity in aphasia rehabilitation and have important clinical
implications for
service delivery models.
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