My three leading candidates are:
1. What are the 1000+ failed neuroprotective research trials that Dr. Michael Tymianski, of the Toronto Western Hospital Research Institute in Canada mentions and what is the common linkage as to why they failed in humans?
2. What are the most promising solutions to the 5 known causes of the neuronal cascade of death?
3. What causes a neuron to drop what it is doing and take on a neighboring neurons function? I.E. exactly how does neuroplasticity work so we can make it repeatable?
Human Computation - The power of crowds
Human computation, a term introduced by Luis von Ahn (1), refers to distributed systems that combine the strengths of humans and computers to accomplish tasks that neither can do
alone (2). The seminal example is
reCAPTCHA, a Web widget used by 100 million people a day when they
transcribe distorted text into
a box to prove they are human. This free
cognitive labor provides users with access to Web content and keeps
websites safe
from spam attacks, while feeding into a massive,
crowd-powered transcription engine that has digitized 13 million
articles
from The New York Times archives (3). But perhaps the best known example of human computation is Wikipedia. Despite initial concerns about accuracy (4),
it has become the key resource for all kinds of basic information.
Information science has begun to build on these early
successes, demonstrating the potential to evolve
human computation systems that can model and address wicked problems
(those
that defy traditional problem-solving methods)
at the intersection of economic, environmental, and sociopolitical
systems.
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