Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 23, 2016

Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): study protocol for a randomized controlled trial

If you are getting an aneurysm fixed what is your doctor doing to precondition the brain in case a stroke occurs? ANYTHING AT ALL? Does your doctor even know anything about this?

Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

 

Novel cellular mechanisms for neuroprotection in ischemic preconditioning: a view from inside organelles

 

Can Blood-Pressure Cuffs Work? Novel Ways to Limit Stroke Damage

 

High altitudes for Training the Brain to Survive Stroke.

Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): study protocol for a randomized controlled trial 
Selma Tülü1, Miriam Mulino1, Daniel Pinggera1, Markus Luger2, Philipp Würtinger3, Astrid Grams4, Thomas Bodner5, Ronny Beer5, Raimund Helbok5, Raffaella Matteucci-Gothe6, Claudia Unterhofer1, Elke Gizewski4, Erich Schmutzhard5, Claudius Thomé1 and Martin Ortler1*
Author Affiliations

1 Department of Neurosurgery, Medical University of Innsbruck, 35, Anichstrasse, Innsbruck 6020, Austria
2 Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck 6020, Austria
3 Central Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Innsbruck, Innsbruck 6020, Austria
4 Department of Neuroradiology, Medical University of Innsbruck, Innsbruck 6020, Austria
5 Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, Austria
6 Department of Public Health and Health Technology Assessment, UMIT Health and Life Sciences University, Hall in Tirol, Austria
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Trials 2015, 16:594  doi:10.1186/s13063-015-1102-6
The electronic version of this article is the complete one and can be found online at: http://www.trialsjournal.com/content/16/1/594

Received:8 March 2015
Accepted:3 December 2015
Published:29 December 2015
© 2015 Tülü et al.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


Abstract

Background

The treatment of intracranial aneurysms may be associated with cerebral ischemia. We hypothesize that pre-interventional remote ischemic preconditioning (RIPC) reduces ischemic cerebral tissue damage in patients undergoing elective intracranial aneurysm treatment.

Methods/Design

This study is a single-center, prospective, randomized, double-blind explorative trial. Patients with an unruptured intracranial aneurysm admitted to Innsbruck Medical University Hospital for coiling or clipping will be consecutively randomized to either the intervention group (= RIPC by inflating an upper extremity blood-pressure cuff for 3 x 5 min to 200 mmHg) or the control group after induction of anesthesia. Participants will be randomized 1:1 to either the preconditioning group or the sham group using a random allocation sequence and block randomization. The precalculated sample size is n = 24 per group. The primary endpoint is the area-under-the-curve concentration of serum biomarkers (S100B, NSE, GFAP, MMP9, MBP, and cellular microparticles) in the first five days after treatment. Secondary endpoints are the number and volume of new ischemic lesions in magnetic resonance imaging and clinical outcome evaluated with the National Institutes of Health Stroke Scale, the modified Rankin Scale, and neuropsychological tests at six and twelve months. All outcome variables will be determined by observers blinded to group allocation. This study was approved by the local institutional Ethics Committee (UN5164), version 3.0 of the study protocol, dated 20 October 2013.

Discussion

This study uses the elective treatment of intracranial aneurysms as a paradigmatic situation to explore the neuroprotective effects of RIPC. If effects are demonstrable in this pilot trial, a larger, prospective phase III trial will be considered.

 

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