http://www.nature.com/articles/srep19521
- Scientific Reports 6, Article number: 19521 (2016)
- doi:10.1038/srep19521
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- Received:
- Accepted:
- Published online:
Abstract
Acupuncture
has been used for patients with stroke and post-stroke rehabilitation
for thousands of years. Previous studies reported that acupuncture
enhanced stroke recovery through neurogenesis. Hence, we conducted a
systematic review and meta-analysis for preclinical studies to assess
the current evidence for acupuncture effect on neurogenesis in treating
ischaemic stroke. Studies were obtained from six databases, including
PubMed, EMBASE, Cochrane Library, Chinese National Knowledge
Infrastructure, VIP information database, and Chinese Biomedical
Literature Database, Ultimately, 34 studies containing 1617 animals were
identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and
GFAP were selected as major outcomes. The pooled results of 15 studies
marked with Brdu showed significant effects of acupuncture for improving
proliferation when compared with control groups (P < 0.01);
13 studies marked with Nestin showed significant effects of acupuncture
for increasing proliferation when compared with control groups (P
< 0.01); 4 studies marked with PSA-NCAM showed significant effects of
acupuncture for enhancing migration when compared with control groups (P
< 0.01); 4 studies marked with NeuN showed significant effects of
acupuncture for stimulating differentiation when compared with control
groups (P < 0.01). The findings suggest that acupuncture is a prospective therapy targeting neurogenesis for ischemic stroke.
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