Deans' stroke musings: The brain functional connectome is robustly altered by lack of sleep

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, January 4, 2016

The brain functional connectome is robustly altered by lack of sleep

What is your doctors sleep protocol? Does use of a sleeping pill constitute 'real' sleep? I was completely exhausted every day while in the hospital. I never got enough sleep. I had these fucking vampires drawing blood every morning from someone in the 4 plex at 7am. Who is most important? The workers at the hospital or the patients? This likely requires a call to the president. For your best recovery your doctor should know exactly how many hours of sleep you require.
http://www.ncbi.nlm.nih.gov/pubmed/26712339

Kaufmann T¹, Elvsåshagen T², Alnæs D³, Zak N⁴, Pedersen PØ⁵, Norbom LB⁶, Quraishi SH⁷, Tagliazucchi E⁸, Laufs H⁸, Bjørnerud A⁹, Malt UF¹⁰, Andreassen OA¹¹, Roussos E¹², Duff EP¹², Smith SM¹², Groote IR¹³, Westlye LT¹⁴.

Author information

Abstract

Sleep is a universal phenomenon necessary for maintaining homeostasis and function across a range of organs. Lack of sleep has severe health-related consequences affecting whole-body functioning, yet no other organ is as severely affected as the brain. The neurophysiological mechanisms underlying these deficits are poorly understood. Here, we characterize the dynamic changes in brain connectivity profiles inflicted by sleep deprivation and how they deviate from regular daily variability. To this end, we obtained functional magnetic resonance imaging data from 60 young, adult male participants, scanned in the morning and evening of the same day and again the following morning. 41 participants underwent total sleep deprivation before the third scan, whereas the remainder had another night of regular sleep. Sleep deprivation strongly altered the connectivity of several resting-state networks, including dorsal attention, default mode, and hippocampal networks. Multivariate classification based on connectivity profiles predicted deprivation state with high accuracy, corroborating the robustness of the findings on an individual level. Finally, correlation analysis suggested that morning-to-evening connectivity changes were reverted by sleep (control group)-a pattern which did not occur after deprivation. We conclude that both, a day of waking and a night of sleep deprivation dynamically alter the brain functional connectome.