- The authors derived this sample from the Prospective Population Study of Women and H70 Birth Cohort Study in Gothenburg, Sweden.
- They included 700 dementia–free women aged 70–92 years.
- The women underwent comprehensive neuropsychiatric and somatic examinations, at baseline in 2000–2001, and at follow–up in 2005–2006.
- They performed a CT scan in 447 participants at baseline.
- They collected information on the use and dosage of calcium supplements, and diagnosed dementia according to DSM–III–R criteria.
- As compare to women not given supplementation (n = 602), the women who treated with calcium supplements (n = 98) were at a higher risk of developing dementia (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.01–4.37, p = 0.046) and the subtype stroke–related dementia (vascular dementia and mixed dementia) (OR 4.40, 95% CI 1.54–12.61, p = 0.006).
- As per this stratified analyses, calcium supplementation was connected with the development of dementia in groups with a history of stroke (OR 6.77, 95% CI 1.36–33.75, p = 0.020) or presence of white matter lesions (OR 2.99, 95% CI 1.28–6.96, p = 0.011), but not in groups without these conditions.