http://www.mdlinx.com/internal-medicine/medical-news-article/2016/08/22/cerebrovascular-disease-calcium-supplementation-dementia/6824758/?
Neurology®, 08/22/2016
This
longitudinal population–based study coordinated to describe the
association between calcium supplementation with the development of
dementia in women with cerebrovascular disease after a 5–year follow–up.
The study found that calcium supplementation may increase the risk of
developing dementia in elderly women. These findings need to be
confirmed, because this sample was relatively small and the study was
observational.
Methods
- The authors derived this sample from the Prospective Population Study of Women and H70 Birth Cohort Study in Gothenburg, Sweden.
- They included 700 dementia–free women aged 70–92 years.
- The women underwent comprehensive neuropsychiatric and somatic examinations, at baseline in 2000–2001, and at follow–up in 2005–2006.
- They performed a CT scan in 447 participants at baseline.
- They collected information on the use and dosage of calcium supplements, and diagnosed dementia according to DSM–III–R criteria.
Results
- As compare to women not given supplementation (n = 602), the women who treated with calcium supplements (n = 98) were at a higher risk of developing dementia (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.01–4.37, p = 0.046) and the subtype stroke–related dementia (vascular dementia and mixed dementia) (OR 4.40, 95% CI 1.54–12.61, p = 0.006).
- As per this stratified analyses, calcium supplementation was connected with the development of dementia in groups with a history of stroke (OR 6.77, 95% CI 1.36–33.75, p = 0.020) or presence of white matter lesions (OR 2.99, 95% CI 1.28–6.96, p = 0.011), but not in groups without these conditions.
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