Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, August 27, 2016

Effects of alteplase for acute stroke on the distribution of functional outcomes

They still don't bother to tell you that tPA getting to full recovery has a horrifying 88% failure rate. Damn I hate these 'happy talk' research articles. Because of this fucking 'happy talk' no one is looking for a better replacement.
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/08/23/confidence-interval-odds-ratio-stroke-thrombolytic/6828728/?
Stroke, 08/23/2016
The clinicians intended to evaluate the effects of alteplase for acute stroke on the distribution of functional outcomes. The study reveal that treatment with intravenous alteplase started within 4.5 hours of stroke onset increases the chance of achieving an improved level of function for all patients across the age spectrum, including the over 80s and across all severities of stroke studied; the earlier that treatment is initiated, the greater the benefit.

Methods

  • From 9 randomized trials, prespecified pooled analysis of 6756 patients comparing alteplase vs. placebo/open control.
  • For this study, ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant interaction term(s).

Results

  • Treatment with alteplase was favourable for a delay in treatment extending to 4.5 hours after stroke onset, with a greater benefit with earlier treatment.
  • The study reveal that, neither age nor stroke severity significantly affected the slope of the relationship between benefit and time to treatment initiation.
  • As per the study, for the observed case mix of patients treated within 4.5 hours of stroke onset (mean 3 hours and 20 minutes), the net absolute benefit from alteplase (ie, the difference between those who would do better if given alteplase and those who would do worse) was 55 patients per 1000 treated (95% confidence interval, 13–91; P=0.004).

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