Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 13, 2016

Small-World Characteristics of Cortical Connectivity Changes in Acute Stroke

I can see no usefulness for survivors in this. Ask your doctor what small-worldness is.
http://nnr.sagepub.com/content/31/1/81?etoc
  1. Pietro Caliandro, MD, PhD1,2⇑
  2. Fabrizio Vecchio, PhD3
  3. Francesca Miraglia, PhD3
  4. Giuseppe Reale, MD1
  5. Giacomo Della Marca, MD, PhD1
  6. Giuseppe La Torre, PhD4
  7. Giordano Lacidogna, MD1
  8. Chiara Iacovelli, PhD1,2
  9. Luca Padua, MD, PhD1,2
  10. Placido Bramanti, MD5
  11. Paolo Maria Rossini, MD, PhD1,3
  1. 1Catholic University, Rome, Italy
  2. 2Fondazione Don Carlo Gnocchi Onlus, Milan, Italy
  3. 3IRCCS San Raffaele Pisana, Rome, Italy
  4. 4Sapienza University of Rome, Rome, Italy
  5. 5IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  1. Pietro Caliandro, Università Cattolica del Sacro Cuore, Policlinico Gemelli, Institute of Neurology, Largo F. Vito 1, 00168 Rome, Italy. Email: pietro.caliandro@policlinicogemelli.it

Abstract


Background. After cerebral ischemia, disruption and subsequent reorganization of functional connections occur both locally and remote to the lesion. Recently, complexity of brain connectivity has been described using graph theory, a mathematical approach that depicts important properties of complex systems by quantifying topologies of network representations. Functional and dynamic changes of brain connectivity can be reliably analyzed via electroencephalography (EEG) recordings even when they are not yet reflected in structural changes of connections. 
 Objective. We tested whether and how ischemic stroke in the acute stage may determine changes in small-worldness of cortical networks as measured by cortical sources of EEG.  
Methods. Graph characteristics of EEG of 30 consecutive stroke patients in acute stage (no more than 5 days after the event) were examined. Connectivity analysis was performed using eLORETA in both hemispheres.  
Results. Network rearrangements were mainly detected in delta, theta, and alpha bands when patients were compared with healthy subjects. In delta and alpha bands similar findings were observed in both hemispheres regardless of the side of ischemic lesion: bilaterally decreased small-worldness in the delta band and bilaterally increased small-worldness in the alpha2 band. In the theta band, bilaterally decreased small-worldness was observed only in patients with stroke in the left hemisphere. Conclusions. After an acute stroke, brain cortex rearranges its network connections diffusely, in a frequency-dependent modality probably in order to face the new anatomical and functional frame.
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