- For this research, they designed a prospective cohort study.
- A sum of 1226 Australian women aged 70–85 y without prevalent ASVD and/or diabetes were enlisted in 1998 and were studied for 15 y.
- They evaluated demographic and ASVD risk factors at baseline (1998), and they utilized a validated food–frequency questionnaire to assess dietary consumption.
- Nitrate consumption from vegetables was calculated by utilization of a newly developed comprehensive database.
- The primary outcome was any death attributed to ASVD ascertained by utilizing linked data that were provided via the Western Australian Data Linkage system.
- They utilized Cox proportional hazards modeling to inspect the relationship between nitrate consumption and ASVD mortality before and after adjustment for lifestyle and cardiovascular disease risk factors.
- Amid a follow–up period of 15,947 person–years, 238 of 1226 (19.4%) women died of ASVD–related causes.
- The mean ± SD vegetable nitrate consumption was 67.0 ± 29.2 mg/d.
- Each SD higher vegetable nitrate consumption was related to a lower risk of ASVD mortality in both unadjusted [HR: 0.80 (95% CI: 0.70, 0.92), P = 0.002] and multivariable–adjusted [HR: 0.79 (95% CI: 0.68, 0.93), P = 0.004] examinations.
- This connection was attenuated after further adjustment for diet quality [HR: 0.85 (95% CI: 0.72, 1.01), P = 0.072].
- Higher vegetable nitrate consumption (per SD) also was related to a lower risk of all–cause mortality [Multivariable–adjusted HR: 0.87 (95% CI: 0.78, 0.97), P = 0.011].