https://www.mdlinx.com/internal-medicine/medical-news-article/2017/06/01/atherosclerosis-atherosclerotic-vascular-disease-cardiovascular-diseases/7194908/?
American Journal of Clinical Nutrition
Blekkenhorst LC, et al.
This article was composed
with the goal to explore the relationship of nitrate consumption from
vegetables with atherosclerotic vascular disease (ASVD) mortality.
Nitrate consumption from vegetables was inversely connected with ASVD
mortality independent of lifestyle and cardiovascular disease risk
factors in this population of older adult women without prevalent ASVD
or diabetes. These outcomes support the concept that nitrate–rich
vegetables may decrease the risk of age–related ASVD mortality.
Methods
- For this research, they designed a prospective cohort study.
- A sum of 1226 Australian women aged 70–85 y without prevalent ASVD and/or diabetes were enlisted in 1998 and were studied for 15 y.
- They evaluated demographic and ASVD risk factors at baseline (1998), and they utilized a validated food–frequency questionnaire to assess dietary consumption.
- Nitrate consumption from vegetables was calculated by utilization of a newly developed comprehensive database.
- The primary outcome was any death attributed to ASVD ascertained by utilizing linked data that were provided via the Western Australian Data Linkage system.
- They utilized Cox proportional hazards modeling to inspect the relationship between nitrate consumption and ASVD mortality before and after adjustment for lifestyle and cardiovascular disease risk factors.
Results
- Amid a follow–up period of 15,947 person–years, 238 of 1226 (19.4%) women died of ASVD–related causes.
- The mean ± SD vegetable nitrate consumption was 67.0 ± 29.2 mg/d.
- Each SD higher vegetable nitrate consumption was related to a lower risk of ASVD mortality in both unadjusted [HR: 0.80 (95% CI: 0.70, 0.92), P = 0.002] and multivariable–adjusted [HR: 0.79 (95% CI: 0.68, 0.93), P = 0.004] examinations.
- This connection was attenuated after further adjustment for diet quality [HR: 0.85 (95% CI: 0.72, 1.01), P = 0.072].
- Higher vegetable nitrate consumption (per SD) also was related to a lower risk of all–cause mortality [Multivariable–adjusted HR: 0.87 (95% CI: 0.78, 0.97), P = 0.011].
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