Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies

Well shit, a review and meta-analysis are not going to give you answers or protocols on dementia prevention. Do some actual research you blithering idiots.
http://bmjopen.bmj.com/content/7/10/e014706

1. Wei Xu1,
2. Hui Fu Wang2,
3. Yu Wan2,
4. Chen-Chen Tan2,
5. Jin-Tai Yu2,
6. Lan Tan1,2

Author affiliations

1. Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
2. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China

1. Correspondence to Professor Jin-Tai Yu; yujintaiqd@163.com and Dr. Lan Tan; dr.tanlan@163.com

Abstract

Background There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose–response relationship is still unclear.

Objective To quantitatively investigate the relationship between dementia and PA.

Design PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose–response relationship using two stage generalised least squares regression.

Results The primary analysis exhibited a dose–response trend for all-cause dementia (ACD), Alzheimer’s disease (AD) but not for vascular dementia (VD). In the dose–response analysis, either ACD (p_trend <0.005; p_{non-linearity}=0.87) or AD (p _trend <0.005; p_{non-linearity}=0.10) exhibited a linear relationship with leisure time PA (LTPA) over the observed range (0–2000 kcal/week or 0–45 metabolic equivalent of task hours per week (MET-h/week)). Specifically, for every 500 kcal or 10 MET-h increase per week, there was, on average, 10% and 13% decrease in the risk of ACD and AD, respectively.

Conclusions We have reported, for the first time, the dose–response relationship between LTPA and dementia, further supporting the international PA guideline from the standpoint of dementia prevention.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

http://dx.doi.org/10.1136/bmjopen-2016-014706