Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 30, 2020

Physical exercise ameliorates the cognitive function and attenuates the neuroinflammation of Alzheimer disease via miR-129–5p

It is YOUR DOCTOR'S RESPONSIBILITY to get you recovered enough to do the exercises needed to prevent Alzheimers. If your doctor can't extrapolate this research from mice to humans then you need more help than exists from the stroke medical world. Good luck. 

Physical exercise ameliorates the cognitive function and attenuates the neuroinflammation of Alzheimer disease via miR-129–5p

Li Z, Chen Q, Liu J
Dementia and Geriatric Cognitive Disorders|May 21, 2020
Given that physical exercise plays an important neuroprotective role in Alzheimer disease (AD), but the underlying mechanisms remain unknown, researchers explored physical exercise molecular mechanisms by analyzing the role of microRNA-129–5p (miR-129–5p) in mice and patients with AD. AD mice and patients, respectively, were treated for 4-week and 3-month physical exercise. Using quantitative real-time PCR, the expression of miR-129–5p was measured. All of the evidence showed that the physical exercise significantly upregulates miR-129–5p expression in AD mice and patients. The knockdown of miR-129–5p may abrogate exercise's neuroprotective effect on cognition and neuroinflammation in AD mice. This research offers a novel insight into the molecular mechanisms underlying the neuroprotective impact of physical exercise in AD, and miR-129–5p may serve as a novel therapeutic target for AD.


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