Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 29, 2020

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance

DId your doctor and stroke hospital get research going on therapeutic targets in patients with acute stroke? It has only been 3 years. If nothing was done, WHY THE HELL HAVEN'T YOU FIRED THE BOARD OF DIRECTORS? They are the responsible party setting the goals of the stroke hospital. If their goal is not 100% recovery, they don't belong there. 

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance February 2017 

Juana Vallés
,

Aida Lago
,
María Teresa Santos
,
Ana María Latorre
,
José I. Tembl
,
Juan B. Salom
,
Candela Nieves
,
Antonio Moscardó
› Author Affiliations Financial support: This work was supported in part by grants from the Spanish Fondo de Investigaciones Sanitarias Carlos III [FIS13/00016] Fondos FEDER, una forma de hacer Europa, Fundación Española de Trombosis y Hemostasia, Sociedad Valenciana de Cardiología, Consellería Valenciana d’Educació (ACIF/2016/465), GV and RETICS networks INVICTUS (RD12/0014/0004) and INVICTUS+ (RD16/0019/0008) ‘Instituto de Salud Carlos III’.

Further Information

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Summary

Neutrophil extracellular traps (NETs) are networks of DNA, histones, and proteolytic enzymes produced by activated neutrophils through different mechanisms. NET formation is promoted by activated platelets and can in turn activate platelets, thus favoring thrombotic processes. NETs have been detected in venous and arterial thrombosis, but data in stroke are scarce. The aim of this study was to evaluate NETs in the plasma of patients with acute ischemic stroke and their potential association with baseline clinical characteristics, stroke severity, and one-year clinical outcomes. The study included 243 patients with acute ischemic stroke. Clinical and demographic data and scores of stroke severity (NIHSS and mRs) at onset and discharge were recorded. Markers of NETs (cell-free DNA, nucleosomes, and citrullinated histone 3 (citH3)), were determined in plasma. Patients were followed-up for 12 months after the ischemic event. NETs were significantly elevated in the plasma of patients with acute ischemic stroke when compared to healthy subjects. NETs were increased in patients who were over 65 years of age and in those with a history of atrial fibrillation (AF), cardioembolic stroke, high glucose levels, and severe stroke scores at admission and discharge. In multivariate analysis, elevated levels of citH3, the most specific marker of NETs, at onset were independently associated with AF and all-cause mortality at oneyear follow-up. NETs play a role in the pathophysiology of stroke and are associated with severity and mortality. In conclusion, citH3 may constitute a useful prognostic marker and therapeutic target in patients with acute stroke.

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