Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,332 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Friday, May 29, 2020
Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance
DId your doctor and stroke hospital get research going on therapeutic targets in patients with acute stroke? It has only been 3 years. If nothing was done, WHY THE HELL HAVEN'T YOU FIRED THE BOARD OF DIRECTORS? They are the responsible party setting the goals of the stroke hospital. If their goal is not 100% recovery, they don't belong there.
› Author AffiliationsFinancial support:
This work was supported in part by grants from the Spanish Fondo de
Investigaciones Sanitarias Carlos III [FIS13/00016] Fondos FEDER, una
forma de hacer Europa, Fundación Española de Trombosis y Hemostasia,
Sociedad Valenciana de Cardiología, Consellería Valenciana d’Educació
(ACIF/2016/465), GV and RETICS networks INVICTUS (RD12/0014/0004) and
INVICTUS+ (RD16/0019/0008) ‘Instituto de Salud Carlos III’.
Neutrophil extracellular traps (NETs) are networks of DNA, histones,
and proteolytic enzymes produced by activated neutrophils through
different mechanisms. NET formation is promoted by activated platelets
and can in turn activate platelets, thus favoring thrombotic processes.
NETs have been detected in venous and arterial thrombosis, but data in
stroke are scarce. The aim of this study was to evaluate NETs in the
plasma of patients with acute ischemic stroke and their potential
association with baseline clinical characteristics, stroke severity, and
one-year clinical outcomes. The study included 243 patients with acute
ischemic stroke. Clinical and demographic data and scores of stroke
severity (NIHSS and mRs) at onset and discharge were recorded. Markers
of NETs (cell-free DNA, nucleosomes, and citrullinated histone 3
(citH3)), were determined in plasma. Patients were followed-up for 12
months after the ischemic event. NETs were significantly elevated in the
plasma of patients with acute ischemic stroke when compared to healthy
subjects. NETs were increased in patients who were over 65 years of age
and in those with a history of atrial fibrillation (AF), cardioembolic
stroke, high glucose levels, and severe stroke scores at admission and
discharge. In multivariate analysis, elevated levels of citH3, the most
specific marker of NETs, at onset were independently associated with AF
and all-cause mortality at oneyear follow-up. NETs play a role in the
pathophysiology of stroke and are associated with severity and
mortality. In conclusion, citH3 may constitute a useful prognostic
marker and therapeutic target in patients with acute stroke.
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