Deans' stroke musings: CV comorbidities not including stroke may be lower in Parkinson’s disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 27, 2020

CV comorbidities not including stroke may be lower in Parkinson’s disease

So you have a risk of getting Parkinson's from your stroke and then you have a higher risk of having a stroke from having Parkinson's. IT IS YOUR DOCTOR'S RESPONSIBILITY TO PREVENT PARKINSON'S IN THE FIRST PLACE.

Parkinson’s Disease May Have Link to Stroke March 2017

The latest here:

CV comorbidities not including stroke may be lower in Parkinson’s disease

Patients with Parkinson’s disease had higher rates of stroke and lower rates of CAD and vascular disease risk factors, researchers found.

“The main findings of our study are plausibly explained by the impact of low sympathetic tone on cardiovascular factors among patients with [Parkinson’s disease],” Ashraf Abugroun, MD, assistant professor in the division of general internal medicine at Medical College of Wisconsin in Milwaukee, and colleagues wrote in the study published in The American Journal of Cardiology.

Researchers analyzed data from 57,914 participants (mean age, 79 years, 42% women) from the National Inpatient Sample aged 65 years and older with Parkinson’s disease. Participants with Parkinson’s disease were frequency-matched by sex and age to controls (n = 289,570).

Outcomes of interest included hyperlipidemia, hypertension, CAD, diabetes and stroke.

Patients with Parkinson’s disease had lower odds for diabetes (adjusted OR = 0.73; 95% CI, 0.71-0.75), hyperlipidemia (aOR = 0.77; 95% CI, 0.75-0.79), CAD (aOR = 0.64; 95% CI, 0.63-0.66) and hypertension (aOR = 0.68; 95% CI, 0.67-0.7). These patients had higher odds for stroke (aOR = 1.27; 95% CI, 1.24-1.31).

Propensity score-based matched analyses resulted in identical findings.

“In [Parkinson’s disease], where generalized sympathetic denervation has widely been described, the integrity of the hypothalamic-pituitary-adrenal axis will also be compromised leading to blunted circadian rhythms of cortisol and catecholamines as well as lower levels of renin and aldosterone,” Abugroun and colleagues wrote. “As a result, lower blood pressures, blood glucose measurements and triglyceride levels detected in the [Parkinson’s disease] population compared to the general population, as seen in the current study are all theoretically consistent with and can be attributed to an underlying suppressed sympathetic nervous system.”