What research have you initiated to reduce this risk of stroke to zero? We have NO LEADERSHIP you can pass this off to accomplish. What is the protocol for testing this and have you distributed this to all 10 million yearly stroke survivors now and into the future?
Effect of genetic liability to visceral adiposity on stroke and its subtypes: A Mendelian randomization study
Abstract
Aims
The purpose of this study was to investigate the role and genetic effect of visceral adipose tissue accumulation on stroke and its subtypes.
Methods
In this two-sample Mendelian randomization study, genetic variants (221 single nucleotide polymorphisms; P < 5 × 10−8) using as instrumental variables for Mendelian randomization analysis was obtained from a genome-wide association study of visceral adipose tissue. The outcome datasets for stroke and its subtypes were obtained from the MEGASTROKE consortium (up to 67,162 cases and 453,702 controls). Mendelian randomization standard analysis (inverse variance weighted method) was conducted to investigate the effect of genetic liability to visceral adiposity on stroke and its subtypes. Sensitivity analyses (Mendelian randomization-Egger, weighted median, Mendelian randomization-pleiotropy residual sum and outlier) were also utilized to assess horizontal pleiotropy and remove outliers. Multi-variable Mendelian randomization analysis was employed to adjust potential confounders.
Results
In the standard Mendelian randomization analysis, genetically determined visceral adiposity (per 1 SD) was significantly associated with a higher risk of stroke (odds ratio (OR) 1.30; 95% confidence interval (CI) 1.21–1.41, P = 1.48× 10−11), ischemic stroke (OR 1.30; 95% CI 1.20–1.41, P = 4.01 × 10−10) and large artery stroke (OR 1.49; 95% CI 1.22–1.83, P = 1.16 × 10−4). The significant association was also found in sensitivity analysis and multi-variable Mendelian randomization analysis.
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